{"id":"W2921298834","doi":"10.1158/1078-0432.ccr-18-3767","title":"PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Rosetrees Trust; Royal College of Surgeons of England; National Institute for Health and Care Research; Sarcoma UK; Cancer Research UK; Wellcome Trust; Wellcome","keywords":"Oncolytic virus; Sarcoma; Medicine; Soft tissue sarcoma; Cancer research; Blockade; Vaccinia; Immune checkpoint; In vivo; Ex vivo; Immune system; Immunology; Immunotherapy; Pathology; Internal medicine; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007414783,0.0002805943,0.0002411824,0.0001294891,0.00007294443,0.0001869279,0.0001738409,0.0001494194,0.001001806],"category_scores_gemma":[0.00008436007,0.00007594928,0.0001479332,0.0000585969,0.0001907469,0.000116197,0.000105157,0.0005951427,0.0002288743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645133,"about_ca_system_score_gemma":0.0002191061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003479216,"about_ca_topic_score_gemma":0.0004843511,"domain_scores_codex":[0.9999431,0.000007855258,0.000003422109,0.00001281884,0.0000103704,0.00002233797],"domain_scores_gemma":[0.9999341,0.00001458429,0.00001854248,0.000008477135,0.000004959579,0.0000192778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004729429,0.0003360406,0.0003008115,0.00005076968,0.000005803299,0.00003942579,0.00001812877,0.0001858579,0.9929044,0.00005634675,0.00007560975,0.005553972],"study_design_scores_gemma":[0.0001124119,0.006318407,0.003909287,0.00001073353,0.00002117406,0.0002680608,0.00002270575,0.001491546,0.986774,0.00003107859,0.001037539,0.000003044307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982078,0.0005333147,0.0006709691,0.00002158275,0.00001520303,0.00002522204,0.00005512584,0.00004379893,0.0004269291],"genre_scores_gemma":[0.9984872,0.0002314641,0.0004103455,0.00001325007,0.000006832608,0.00001960646,0.0001311273,0.000007062365,0.000693131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001806,"threshold_uncertainty_score":0.00335139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04330766504549396,"score_gpt":0.4263609598860653,"score_spread":0.3830532948405714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}