{"id":"W2921318916","doi":"10.14309/00000434-201810001-00627","title":"Selective Inhibition of Tyrosine Kinase 2 (TYK2) with BMS-986165 Is Efficacious in IL-23-Mediated Diseases: Evidence from Preclinical IBD Models and From a Psoriasis Study","year":2018,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Medicine; Colitis; Psoriasis; Immunology; Pharmacology; Inflammatory bowel disease; CD40; Internal medicine; In vitro; Disease; Cytotoxic T cell; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004052663,0.0005215704,0.0005859925,0.0002691202,0.0001445255,0.0003511149,0.0002297771,0.0002790983,0.001529172],"category_scores_gemma":[0.0001439854,0.0001625613,0.0003632628,0.0002266307,0.0003524672,0.0002835085,0.0001299309,0.001057165,0.0003924194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001759052,"about_ca_system_score_gemma":0.0002121417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000194572,"about_ca_topic_score_gemma":0.0005575351,"domain_scores_codex":[0.9998347,0.0000403518,0.00001927918,0.00002677783,0.0000445718,0.00003434739],"domain_scores_gemma":[0.9998842,0.00002138395,0.00003813035,0.00001250391,0.00001097766,0.00003278445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008052171,0.001849827,0.000677274,0.0004041298,0.0001062935,0.00009867035,0.00003540066,0.0002818103,0.964965,0.0001160649,0.0002712869,0.02314195],"study_design_scores_gemma":[0.0109039,0.0949472,0.01940027,0.00007547045,0.0005865441,0.00123246,0.00007616007,0.001204108,0.8636046,0.0001493925,0.007788245,0.00003160716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879817,0.009050921,0.0008443955,0.0001616654,0.00004750561,0.0001092754,0.0002110411,0.00006158451,0.001531908],"genre_scores_gemma":[0.9920505,0.005731964,0.0007295539,0.00008698305,0.00005809503,0.00007172643,0.0004148431,0.00001089142,0.0008454627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529172,"threshold_uncertainty_score":0.005115569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02805109261094773,"score_gpt":0.3092448629795582,"score_spread":0.2811937703686105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}