{"id":"W2921376680","doi":"10.1093/jcag/gwz006.026","title":"A27 THE SUSTAINED ANTINOCICEPTIVE EFFECT OF ENDOGENOUS OPIOIDS IN PRECLINICAL MODEL OF IBD IS MEDIATED BY COMPARTMENTALIZED ENDOSOMAL SIGNALING BY DELTA OPIOID RECEPTORS","year":2019,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Pharmacology; DADLE; DAMGO; Opioid; Chemistry; μ-opioid receptor; Nociception; Medicine; Receptor; Opioid receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001543733,0.0001318584,0.0005304607,0.00008401189,0.00002999641,0.000004347171,0.0003727857,0.0002036208,0.00005015314],"category_scores_gemma":[0.0004643302,0.00008822134,0.000221094,0.00009882529,0.00007581485,0.000007978417,0.00005680622,0.0002644424,4.626147e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002693972,"about_ca_system_score_gemma":0.0002068816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009103113,"about_ca_topic_score_gemma":0.004477315,"domain_scores_codex":[0.9977245,0.0008924899,0.0006899486,0.0001373853,0.000232232,0.000323409],"domain_scores_gemma":[0.9982292,0.0002519389,0.001143406,0.0001152488,0.0001566403,0.0001035664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001006863,0.00007050251,0.3126831,0.00001781767,0.0001399326,6.509401e-7,0.000108813,0.0005824409,0.6833043,0.000002712606,0.002054935,0.00002794953],"study_design_scores_gemma":[0.01086909,0.006665797,0.008700151,0.00007770928,0.0001314424,0.000009175864,0.0001799578,0.002045922,0.9706904,0.0000581999,0.0004473261,0.0001247814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984333,0.00008935631,0.00002506898,0.0006104812,0.0002560627,0.0003630227,0.0001898989,6.93702e-7,0.00003213651],"genre_scores_gemma":[0.999286,0.0000779521,0.00004480582,0.0004772984,0.00002441257,0.000005359033,0.00003514933,0.000009435307,0.00003958107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.303983,"threshold_uncertainty_score":0.3597562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057967133013099,"score_gpt":0.2541250840582886,"score_spread":0.2435454127281576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}