{"id":"W2921376680","doi":"10.1093/jcag/gwz006.026","title":"A27 THE SUSTAINED ANTINOCICEPTIVE EFFECT OF ENDOGENOUS OPIOIDS IN PRECLINICAL MODEL OF IBD IS MEDIATED BY COMPARTMENTALIZED ENDOSOMAL SIGNALING BY DELTA OPIOID RECEPTORS","year":2019,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Pharmacology; DADLE; DAMGO; Opioid; Chemistry; μ-opioid receptor; Nociception; Medicine; Receptor; Opioid receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001506773,0.0003737352,0.000430591,0.0002641648,0.0001761069,0.0002106821,0.0001984751,0.0002934562,0.00429552],"category_scores_gemma":[0.00008576732,0.000146743,0.0004006216,0.0001757094,0.0002161752,0.000296834,0.0001416609,0.001055709,0.0005819257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195624,"about_ca_system_score_gemma":0.0002001833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003981168,"about_ca_topic_score_gemma":0.0006762729,"domain_scores_codex":[0.9998658,0.00001320366,0.00001365159,0.00002894552,0.00003541376,0.0000430063],"domain_scores_gemma":[0.9999357,0.000005578145,0.00001510532,0.000006549609,0.00001282434,0.00002413914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006263445,0.0001463712,0.0002030394,0.0001108038,0.000009036557,0.0000468211,0.00001227259,0.00004072224,0.9957498,0.0000629022,0.0001761844,0.002815662],"study_design_scores_gemma":[0.00015407,0.004677755,0.0142471,0.00003006472,0.00005058186,0.0003896542,0.00006862608,0.001058093,0.9741713,0.00009657221,0.005044265,0.00001184367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888058,0.003871417,0.002346647,0.000363467,0.0001168946,0.00006677952,0.001526705,0.0001331486,0.002769075],"genre_scores_gemma":[0.9848534,0.003187185,0.002596521,0.0002078333,0.00003045296,0.0001929421,0.001915568,0.00002007391,0.006996125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00429552,"threshold_uncertainty_score":0.01436996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057967133013099,"score_gpt":0.2541250840582886,"score_spread":0.2435454127281576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}