{"id":"W2921445913","doi":"10.4049/jimmunol.1800795","title":"4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance Tissue-Resident Memory T Cell Formation during Respiratory Influenza Infection","year":2019,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Effector; Biology; Immunology; CD8; PI3K/AKT/mTOR pathway; Population; T cell; Cytotoxic T cell; Cell biology; Antigen; Cancer research; Immune system; Medicine; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001254714,0.0002211728,0.000334144,0.0002906598,0.0002586397,0.0000390092,0.0002825028,0.0002720444,0.0003193679],"category_scores_gemma":[0.00007301661,0.0001495803,0.00006815395,0.0001925794,0.00006422621,0.0007140912,0.00009281663,0.0007387947,0.0003680747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001827705,"about_ca_system_score_gemma":0.00003940643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002593262,"about_ca_topic_score_gemma":0.00004131822,"domain_scores_codex":[0.9974622,0.001199134,0.0007559309,0.0001748448,0.0001013505,0.0003065472],"domain_scores_gemma":[0.9984965,0.0003149008,0.0006796343,0.0003432635,0.0001516054,0.00001408987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001010967,0.00007304948,0.0003421442,0.00005430021,0.00005581042,0.000003226452,0.007685694,0.0004868966,0.9891266,0.00002909181,0.0005084123,0.0006237927],"study_design_scores_gemma":[0.00150831,0.0008980148,0.02415545,0.00009211626,0.00005411411,0.0004206069,0.00159825,0.00001195586,0.9649774,0.00006300408,0.006064089,0.0001566982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890031,0.00639238,0.0008363953,0.000219189,0.002574733,0.0007147907,0.000001119583,0.00002172934,0.0002365916],"genre_scores_gemma":[0.9979194,0.0005828593,0.00001974828,0.0004313714,0.00006548051,0.00001394435,0.000005507582,0.00001935034,0.0009423377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02414922,"threshold_uncertainty_score":0.6099706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242588688753868,"score_gpt":0.2812830748551458,"score_spread":0.2688571879676071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}