{"id":"W2921455439","doi":"10.1183/13993003.02066-2018","title":"Analysis of the MILES cohort reveals determinants of disease progression and treatment response in lymphangioleiomyomatosis","year":2019,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Heart, Lung, and Blood Institute; U.S. Food and Drug Administration","keywords":"Lymphangioleiomyomatosis; Medicine; Sirolimus; Internal medicine; Placebo; Cohort; Vital capacity; Lung; Lung function; Pathology; Diffusing capacity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001227122,0.0002287892,0.0004208495,0.0003650721,0.0002299895,0.0004403951,0.0003150261,0.0002550409,0.001949655],"category_scores_gemma":[0.002111233,0.0001490289,0.0005114882,0.0002714337,0.0001619077,0.0003062478,0.0006278459,0.0003821287,0.0002968453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001208543,"about_ca_system_score_gemma":0.0001490737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001416173,"about_ca_topic_score_gemma":0.001546724,"domain_scores_codex":[0.999311,0.0002462952,0.0000396971,0.0002080515,0.0001054935,0.00008944199],"domain_scores_gemma":[0.998899,0.0002511854,0.000412132,0.0002073934,0.00006716517,0.0001630699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00134027,0.00002320131,0.9942678,0.000007661282,0.0001404109,0.00007700577,0.00009037589,0.0000748981,0.001338358,0.00004726634,0.0001595994,0.00243312],"study_design_scores_gemma":[0.00002243051,0.0002331045,0.9986576,0.000003539528,0.0000463084,0.0001780165,0.00009580045,0.0002781856,0.000119412,0.00002688706,0.0003354874,0.000003254568],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992437,0.0001163593,0.00009966872,0.00002169976,0.000002467688,0.000005302579,0.0002830962,0.000003952217,0.0002237242],"genre_scores_gemma":[0.999286,0.00002687895,0.00007807169,0.00001363509,0.000006507759,0.000009412822,0.0003839864,0.000004954715,0.0001904964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949655,"threshold_uncertainty_score":0.006522298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04224709757447316,"score_gpt":0.3309259458614213,"score_spread":0.2886788482869481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}