{"id":"W2921549208","doi":"10.1093/jcag/gwz006.274","title":"A275 COMPREHENSIVE GENOMIC ANALYSIS RESULT IN EARLY DETECTION AND IMPLEMENTATION OF IMMUNE CHECK POINT THERAPY TO IMPROVE SURVIVAL FOR PATIENTS WITH INHERITED REPLICATION REPAIR DEFICIENCY GASTROINTESTINAL CANCERS:REPORT FROM THE INTERNATIONAL REPLICATION REPAIR CONSORTIUM","year":2019,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Microsatellite instability; DNA mismatch repair; Lynch syndrome; Colorectal cancer; Cancer; Medicine; Germline mutation; Oncology; Internal medicine; Cancer research; Mutation; Biology; Gene; Genetics; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004982684,0.0002587837,0.0002216923,0.0004356412,0.0002127459,0.0003446861,0.000164891,0.0002694229,0.000899614],"category_scores_gemma":[0.00126649,0.00009793555,0.0003104429,0.0004189019,0.0001654575,0.000116302,0.0001974512,0.0002997435,0.0002258503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005378097,"about_ca_system_score_gemma":0.0006120495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003845421,"about_ca_topic_score_gemma":0.003545481,"domain_scores_codex":[0.9997137,0.00007869767,0.00002329891,0.00005803111,0.0000793186,0.00004682891],"domain_scores_gemma":[0.9992239,0.0002935807,0.000123332,0.00003719653,0.0001776557,0.0001444106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001487705,0.0002543656,0.8813003,0.0001744006,0.0002285823,0.00477348,0.0001912802,0.000426049,0.008588765,0.0001591462,0.007923094,0.09449276],"study_design_scores_gemma":[0.0001150739,0.001310498,0.980051,0.00006096147,0.000234703,0.00585097,0.0001829651,0.0006748238,0.003329053,0.00009253157,0.008075491,0.00002208287],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815498,0.009035783,0.001131802,0.001309908,0.00004554654,0.0001071302,0.00181751,0.0001065167,0.004896031],"genre_scores_gemma":[0.9942543,0.001940154,0.0009323898,0.0006191622,0.00003823578,0.00003779302,0.001494483,0.0000117146,0.0006716203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003845421,"threshold_uncertainty_score":0.007646084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01009540842607237,"score_gpt":0.2600647173621944,"score_spread":0.2499693089361221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}