{"id":"W2921565126","doi":"10.1016/j.biopsych.2019.02.020","title":"M1 Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder","year":2019,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Memory and Neural Mechanisms","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Canadian Institutes of Health Research; Johnson and Johnson; CHDI Foundation; Seaside Therapeutics; AstraZeneca; Bristol-Myers Squibb; National Institutes of Health; Dystonia Medical Research Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neuroscience; Extinction (optical mineralogy); Basolateral amygdala; Psychology; Fear processing in the brain; Fear conditioning; Prefrontal cortex; Amygdala; Context (archaeology); Optogenetics; Muscarinic acetylcholine receptor; Infralimbic cortex; Receptor; Cognition; Medicine; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001637316,0.0003500488,0.0002403803,0.000103665,0.0001924874,0.0002669738,0.0002605489,0.0003992946,0.001401747],"category_scores_gemma":[0.0002060031,0.0001014991,0.0001794256,0.00006891241,0.0003750837,0.0002466911,0.0001366118,0.0004900084,0.0001650936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004613498,"about_ca_system_score_gemma":0.0003283322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001474234,"about_ca_topic_score_gemma":0.00340565,"domain_scores_codex":[0.9999651,0.000008459227,0.000001451759,0.000004378982,0.000004884502,0.00001581785],"domain_scores_gemma":[0.9999601,0.000008609689,0.0000142751,0.000003816731,0.000005825473,0.000007391655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007189931,0.0004682023,0.00625622,0.0009317932,0.0002526535,0.0007208763,0.0003331604,0.0008897145,0.8667177,0.00605938,0.00159055,0.1085899],"study_design_scores_gemma":[0.002449385,0.01560589,0.5263551,0.0006846471,0.00125269,0.004292012,0.002202636,0.005321706,0.3906068,0.02129597,0.02979636,0.0001367197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714317,0.01873519,0.002214504,0.002156569,0.0001140764,0.00005802287,0.0001490356,0.00002798438,0.005112998],"genre_scores_gemma":[0.9872717,0.009693507,0.0009799094,0.0004171206,0.00008007172,0.00003318002,0.00005576621,0.000003741152,0.001464995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001474234,"threshold_uncertainty_score":0.004689336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08548391821388467,"score_gpt":0.3283919753620292,"score_spread":0.2429080571481446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}