{"id":"W2921587626","doi":"10.1093/jcag/gwz006.141","title":"A142 INFLAMMATORY BOWEL DISEASE PATIENTS REQUIRE AN INCREASED ADALIMUMAB DRUG LEVEL TO SIMULTANEOUSLY ACHIEVE CLINICAL AND BIOLOGICAL REMISSION","year":2019,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Adalimumab; Ulcerative colitis; Calprotectin; Medicine; Inflammatory bowel disease; Biomarker; Therapeutic drug monitoring; Internal medicine; Infliximab; Youden's J statistic; Receiver operating characteristic; Faecal calprotectin; Crohn's disease; Gastroenterology; Area under the curve; Clinical significance; Disease; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007238369,0.0001815507,0.0003801336,0.001094366,0.0006230109,0.0009466165,0.0002437069,0.0002565751,0.001892656],"category_scores_gemma":[0.001874403,0.0001239447,0.0003285285,0.001381978,0.0003072113,0.0003100067,0.0002281721,0.0003159787,0.000723213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008791421,"about_ca_system_score_gemma":0.0008856327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01118727,"about_ca_topic_score_gemma":0.02402492,"domain_scores_codex":[0.9991201,0.00013564,0.000134504,0.00008761719,0.0004206339,0.0001015902],"domain_scores_gemma":[0.9979804,0.0003892188,0.0008744197,0.00005989455,0.0004815727,0.0002144383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001434169,0.00004482218,0.9830951,0.00007756959,0.00002269847,0.0005662257,0.00009786992,0.00003825418,0.00101303,0.00004429808,0.0009561795,0.01390055],"study_design_scores_gemma":[0.00000581383,0.0001104427,0.994119,0.00006082017,0.00002486101,0.001666615,0.0002782935,0.0001137337,0.0004644377,0.00002534598,0.003126543,0.000004132782],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866802,0.003820884,0.0004496734,0.0004572228,0.00003708199,0.00007391527,0.001043732,0.00005271073,0.007384615],"genre_scores_gemma":[0.9955409,0.001155904,0.0008868704,0.0003537812,0.00003650481,0.00003041079,0.0008537445,0.000009187191,0.00113257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01118727,"threshold_uncertainty_score":0.02224427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009601251481448754,"score_gpt":0.2427421974358509,"score_spread":0.2331409459544022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}