{"id":"W2921709383","doi":"10.1200/jco.2019.37.7_suppl.141","title":"Final analysis of phase III LATITUDE study in patients (pts) with newly diagnosed high-risk metastatic castration-naïve prostate cancer (NDx-HR mCNPC) treated with abiraterone acetate + prednisone (AA+P) added to androgen deprivation therapy (ADT).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Abiraterone acetate; Clinical endpoint; Hypokalemia; Interim analysis; Internal medicine; Adverse effect; Placebo; Prostate cancer; MedDRA; Hazard ratio; Gastroenterology; Urology; Androgen deprivation therapy; Confidence interval; Randomized controlled trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002040659,0.0007978574,0.001293638,0.0001920645,0.0002534025,0.000686106,0.0004382859,0.0004456794,0.002975692],"category_scores_gemma":[0.001352463,0.0003839724,0.001348713,0.0002650142,0.0003630723,0.0003394035,0.0003811525,0.001042909,0.0007178666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005991597,"about_ca_system_score_gemma":0.001222027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000938745,"about_ca_topic_score_gemma":0.003067574,"domain_scores_codex":[0.9993036,0.0004277588,0.00003522186,0.00007328302,0.00008158527,0.00007845477],"domain_scores_gemma":[0.999325,0.0001467452,0.0001768214,0.00008299846,0.00007923591,0.0001892797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8628414,0.00848537,0.02988284,0.0009450362,0.004644474,0.0003244283,0.0002651454,0.004067175,0.024941,0.0003677657,0.005761485,0.05747386],"study_design_scores_gemma":[0.5328774,0.3332537,0.1106917,0.00009827433,0.003244765,0.0005516289,0.0001194131,0.00183369,0.004093105,0.0005360126,0.01264644,0.00005395547],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840307,0.002848776,0.001149116,0.0002319864,0.00007824842,0.002925199,0.004972753,0.00009829988,0.003665031],"genre_scores_gemma":[0.9776421,0.001422894,0.002709478,0.0004835224,0.0001041117,0.003340402,0.01147573,0.00004727792,0.002774522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002975692,"threshold_uncertainty_score":0.01079214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09064761430012958,"score_gpt":0.4504710675112411,"score_spread":0.3598234532111115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}