{"id":"W2921719364","doi":"10.1007/s00395-019-0726-1","title":"Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion","year":2019,"lang":"en","type":"article","venue":"Basic Research in Cardiology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; University of Toronto; Lawson Health Research Institute; London Health Sciences Centre","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Mitochondrion; Mitochondrial permeability transition pore; Calpain; MPTP; Superoxide; Programmed cell death; Transgene; Internal medicine; Biology; Mitochondrial ROS; Endocrinology; Genetically modified mouse; Cell biology; Apoptosis; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006005956,0.001442402,0.0008233854,0.001723807,0.0005634328,0.0007752694,0.0009584214,0.001546999,0.003477259],"category_scores_gemma":[0.000439574,0.0008197872,0.0006929665,0.0005546036,0.00145351,0.00104026,0.0005696595,0.003195565,0.0004780712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008584694,"about_ca_system_score_gemma":0.000388599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004947353,"about_ca_topic_score_gemma":0.0009958522,"domain_scores_codex":[0.99946,0.00008976752,0.00006554855,0.0001740569,0.0001098552,0.0001007151],"domain_scores_gemma":[0.9985323,0.0001779139,0.0006268515,0.0001178643,0.00006436208,0.0004807191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001496843,0.0002245779,0.0002666379,0.00006063774,0.00002170779,0.0002030102,0.00003501891,0.00006401751,0.9964437,0.0003370581,0.00007447126,0.0007724271],"study_design_scores_gemma":[0.0005668266,0.001387213,0.007254864,0.00003078112,0.0001275374,0.000887831,0.0001046121,0.001599943,0.986313,0.0004211397,0.001286203,0.00001997045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877961,0.001809239,0.00673058,0.0008725266,0.0001741437,0.0001085223,0.001144266,0.0003869476,0.0009777007],"genre_scores_gemma":[0.9858053,0.001144613,0.005857071,0.0003160927,0.0001218689,0.0002125004,0.0007277018,0.0002142161,0.005600682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003477259,"threshold_uncertainty_score":0.01163256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01614717475828399,"score_gpt":0.2948135602167518,"score_spread":0.2786663854584678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}