{"id":"W2921751750","doi":"10.1039/c9nr00364a","title":"Non-invasive isolation of rare circulating tumor cells with a DNA mimic of double-sided tape using multimeric aptamers","year":2019,"lang":"en","type":"article","venue":"Nanoscale","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cape Breton University","funders":"Natural Sciences and Engineering Research Council of Canada; Atlantic Canada Opportunities Agency; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China; Cape Breton University; Beatrice Hunter Cancer Research Institute","keywords":"Aptamer; DNA; Isolation (microbiology); Double stranded; Circulating tumor cell; Double strand; Materials science; Molecular biology; Biophysics; Cancer research; Chemistry; Biology; Genetics; Cancer; Biochemistry; DNA damage; Bioinformatics; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007046985,0.0001461212,0.0002638641,0.00007000381,0.00003241011,0.000005273156,0.00009222129,0.00009987991,0.000003743614],"category_scores_gemma":[0.00001520846,0.0001229878,0.0001102888,0.0002082065,0.00009418758,0.000006725768,0.00004399139,0.00005593534,0.000001038658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001594502,"about_ca_system_score_gemma":0.0000698874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006780469,"about_ca_topic_score_gemma":0.00001751175,"domain_scores_codex":[0.9991208,0.00002210494,0.0002668372,0.0002905725,0.0001378469,0.0001618464],"domain_scores_gemma":[0.9991146,0.0000161452,0.0003578223,0.0003023562,0.0001750537,0.000034048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001621743,0.00004177221,0.006190755,0.00005454713,0.00005436605,0.000001559236,0.00004510118,0.0004660743,0.9927503,8.606224e-7,0.00001204546,0.0002204803],"study_design_scores_gemma":[0.0006952788,0.000272758,0.0005677233,0.0001329888,0.00005950945,0.000009872652,0.0001827096,0.002936177,0.994953,0.000003550447,0.00002500649,0.0001614572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99704,0.0000423281,0.002405162,0.000007185309,0.00003372512,0.0002479742,0.0000145533,0.00001229385,0.0001967597],"genre_scores_gemma":[0.9753088,0.00001258691,0.02446835,0.00003307824,0.00002744619,0.000002251986,0.00005112673,0.00001992265,0.00007645106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02206319,"threshold_uncertainty_score":0.5015298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009170647282519453,"score_gpt":0.2441414580595359,"score_spread":0.2349708107770164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}