{"id":"W2921755475","doi":"10.14288/1.0374139","title":"The clinical actionability and evolution of mutational processes in metastatic cancer","year":2019,"lang":"en","type":"article","venue":"Open Collections","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cancer; Medicine; Genetics; Biology; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002083016,0.00003599704,0.00006797533,0.00001023309,0.0001966749,0.0000678323,0.00007808481,0.00002522235,0.00002950985],"category_scores_gemma":[0.0003169706,0.00002943391,0.00001740326,0.0001874137,0.00005840708,0.000004205438,0.0000693949,0.00003760377,5.210509e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003232692,"about_ca_system_score_gemma":0.0007091071,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002853957,"about_ca_topic_score_gemma":0.02170305,"domain_scores_codex":[0.9995776,0.00003554879,0.0001574221,0.0001320839,0.0000401596,0.000057137],"domain_scores_gemma":[0.9995661,0.0001462551,0.00005650232,0.00009726438,0.0001183818,0.00001551027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00206692,0.001451645,0.7896137,0.0002905597,0.0005609504,0.000001333299,0.0002777305,0.01307463,0.01397906,0.002545622,0.1634548,0.01268302],"study_design_scores_gemma":[0.004686213,0.001106955,0.5991542,0.00006765986,0.0001072323,0.00002509425,0.001522751,0.001597976,0.009371481,0.01423569,0.3676848,0.0004399601],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888989,0.001154553,0.00025681,0.0003709462,0.0003040476,0.0006712026,0.00009876311,0.000001566434,0.008243266],"genre_scores_gemma":[0.9914113,0.0008171936,0.0002446453,0.00003856789,0.00003391833,0.0001220748,0.00001050822,0.000004053772,0.007317754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2042299,"threshold_uncertainty_score":0.9961483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02147328408334787,"score_gpt":0.3458508743005201,"score_spread":0.3243775902171722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}