{"id":"W2921764825","doi":"10.3802/jgo.2019.30.e60","title":"The influence of BRCA variants of unknown significance on cancer risk management decision-making","year":2019,"lang":"en","type":"article","venue":"Journal of Gynecologic Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, New York University; York University","keywords":"Medicine; Genetic testing; Logistic regression; Internal medicine; Family history; Ovarian cancer; Genetic counseling; Gynecology; Oncology; Gynecologic oncology; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002737039,0.0001622569,0.0002317867,0.0006193202,0.0003671362,0.0009436377,0.0002999284,0.0004292217,0.002296898],"category_scores_gemma":[0.02539495,0.0001179548,0.0003397786,0.0004509124,0.0005449594,0.0004320236,0.0004831354,0.0004424885,0.0001594921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005268563,"about_ca_system_score_gemma":0.0007028506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002745914,"about_ca_topic_score_gemma":0.002918249,"domain_scores_codex":[0.9971383,0.001595848,0.0001861556,0.0003391567,0.0004638063,0.0002767834],"domain_scores_gemma":[0.9844742,0.009914893,0.004025541,0.0002313782,0.000402282,0.0009517629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002822056,0.00003325704,0.9955744,0.000008009018,0.00007360939,0.00008529365,0.0000713693,0.0001727998,0.00006118126,0.00003103636,0.00005155768,0.003555318],"study_design_scores_gemma":[0.00002114885,0.0003046927,0.9972294,0.00001777617,0.00005982112,0.0006176664,0.0003250636,0.001085671,0.00009847167,0.00008869413,0.0001463872,0.000005338615],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990337,0.0003831926,0.00005519908,0.0001415413,0.000005356625,0.000003492544,0.00002704663,0.000001275123,0.0003491327],"genre_scores_gemma":[0.9998606,0.00004234774,0.00003933407,0.00001527961,0.000007104594,0.000001224726,0.000016116,5.393055e-7,0.00001742056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002745914,"threshold_uncertainty_score":0.01447505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007597958503391047,"score_gpt":0.3094944901621453,"score_spread":0.3018965316587542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}