{"id":"W2921804231","doi":"10.1158/0008-5472.can-18-1545","title":"SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Jewish General Hospital; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; Government of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Fondation du cancer du sein du Québec","keywords":"Bromodomain; SWI/SNF; Cancer; Medicine; Cancer research; Biology; Internal medicine; Genetics; Transcription factor; Epigenetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005771756,0.000152054,0.000164739,0.000160404,0.0001354522,0.00008461632,0.0003780919,0.0001498789,0.0005025959],"category_scores_gemma":[0.0001241626,0.0001470942,0.00007787205,0.0004421773,0.0000942462,0.00001155375,0.0002314391,0.0002591104,0.0003488469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608431,"about_ca_system_score_gemma":0.0004712009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000630826,"about_ca_topic_score_gemma":0.0004232043,"domain_scores_codex":[0.9980263,0.0001614389,0.0001906774,0.0005649676,0.000486163,0.0005705002],"domain_scores_gemma":[0.9988397,0.00001820726,0.00004929426,0.0005452386,0.0002820721,0.0002654955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000174451,0.00002137784,0.00367739,0.00003502253,0.00002109517,0.000002151596,0.00005296751,0.0001373937,0.9302563,0.00009842742,0.06393642,0.001587003],"study_design_scores_gemma":[0.0006673523,0.0003457941,0.0009773767,0.00006920473,0.000001829865,0.000001158482,0.0002414708,0.00001227914,0.7767355,0.00004593177,0.2207112,0.000190935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939214,0.0007513714,0.00008778316,0.001237947,0.0004613037,0.0008834481,0.0000329172,0.00002189339,0.002601958],"genre_scores_gemma":[0.9830183,0.0001471493,0.0001331352,0.0004495271,0.000646632,0.0002971273,0.0000385585,0.00004110791,0.01522848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1567748,"threshold_uncertainty_score":0.5998327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03389902320710113,"score_gpt":0.3579223199509577,"score_spread":0.3240232967438565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}