{"id":"W2921804231","doi":"10.1158/0008-5472.can-18-1545","title":"SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Jewish General Hospital; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; Government of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Fondation du cancer du sein du Québec","keywords":"Bromodomain; SWI/SNF; Cancer; Medicine; Cancer research; Biology; Internal medicine; Genetics; Transcription factor; Epigenetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009685016,0.0002226251,0.0002027701,0.0002265782,0.00008516935,0.0002065424,0.00008781974,0.0001688792,0.001091785],"category_scores_gemma":[0.0000791108,0.00009180451,0.0001703618,0.00009897721,0.0001590641,0.0001091786,0.0001087024,0.0002861586,0.0002686711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001822434,"about_ca_system_score_gemma":0.00006924884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002185665,"about_ca_topic_score_gemma":0.0003218029,"domain_scores_codex":[0.9999219,0.00001280633,0.000007033077,0.00001564743,0.00002291258,0.00001965289],"domain_scores_gemma":[0.9999434,0.00001069013,0.00001942196,0.000006844492,0.000005566374,0.00001410417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008988421,0.0000158811,0.0002606107,0.000009973229,0.000004473279,0.00002473634,0.000002451688,0.00005976722,0.9989208,0.00002811594,0.00002455719,0.0005587236],"study_design_scores_gemma":[0.00001188987,0.0004877528,0.009548502,0.000002509819,0.00001017396,0.0003631551,0.00001794797,0.0009337243,0.987209,0.00005424682,0.001358768,0.000002347671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969029,0.0009731568,0.001036846,0.00005121939,0.00001254031,0.00001488911,0.0003168259,0.00005987669,0.0006315918],"genre_scores_gemma":[0.9975743,0.0003149707,0.0005186992,0.00002979991,0.000002900252,0.00001453855,0.0004335457,0.000007759128,0.001103558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001091785,"threshold_uncertainty_score":0.003652334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03389902320710113,"score_gpt":0.3579223199509577,"score_spread":0.3240232967438565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}