{"id":"W2921808248","doi":"10.1093/jcag/gwz006.116","title":"A117 CHARACTERIZATION OF A NOVEL GAIN OF FUNCTION MUTATION IN A NON-RECEPTOR TYROSINE KINASE IN THE DEVELOPMENT OF VERY EARLY ONSET INFLAMMATORY BOWEL DISEASE.","year":2019,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation","funders":"","keywords":"Scholarship; Inflammatory bowel disease; Mutation; Function (biology); Government (linguistics); Gain of function; Tyrosine kinase; Medicine; Receptor; Cancer research; Internal medicine; Disease; Political science; Biology; Genetics; Gene; Philosophy; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002205834,0.0003992222,0.0002864715,0.00104913,0.0003556045,0.0004169511,0.0006113794,0.001646383,0.004923969],"category_scores_gemma":[0.001198535,0.0001373143,0.0005912763,0.0004892134,0.0003859037,0.0003055114,0.0003490028,0.0006138696,0.001210161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004263156,"about_ca_system_score_gemma":0.0003423931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001695589,"about_ca_topic_score_gemma":0.001295033,"domain_scores_codex":[0.9997516,0.00003807933,0.00005069983,0.00004469468,0.00006180986,0.00005307594],"domain_scores_gemma":[0.9990147,0.0003955433,0.0001859662,0.00004310482,0.0001325075,0.0002280865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.001101756,0.0002647482,0.02417547,0.0001396435,0.00006777219,0.769448,0.0003461827,0.0004070907,0.1878925,0.002075389,0.002720862,0.01136065],"study_design_scores_gemma":[0.0002877587,0.001603975,0.1604013,0.0001368978,0.0001806843,0.7177851,0.0004785747,0.003293221,0.09609228,0.001041709,0.01863961,0.00005896466],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829333,0.0009017919,0.001591582,0.001215334,0.000417066,0.0001676474,0.001544269,0.00006489341,0.01116414],"genre_scores_gemma":[0.9950615,0.0002078814,0.0009326138,0.0002201316,0.00009249277,0.00001671882,0.00067015,0.0000253656,0.002773061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004923969,"threshold_uncertainty_score":0.01647234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007686194581827261,"score_gpt":0.2209044263578565,"score_spread":0.2132182317760292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}