{"id":"W2921832702","doi":"10.1021/acsomega.8b03595","title":"Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu<sup>2+</sup>","year":2019,"lang":"en","type":"article","venue":"ACS Omega","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; York University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tau protein; Chemistry; Microtubule; Reactive oxygen species; Biophysics; Protein aggregation; Oxidative stress; Redox; Binding site; Plasma protein binding; Glutathione; Biochemistry; Stereochemistry; Cell biology; Alzheimer's disease; Biology; Enzyme; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001482265,0.0001428368,0.0003226534,0.0001550913,0.00003349953,0.000008642918,0.0001006169,0.00009222743,0.0001267323],"category_scores_gemma":[0.00008276652,0.0001178091,0.00009529984,0.0003163364,0.0000683622,0.0001285418,0.0000512182,0.0001156227,0.0002032896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006517812,"about_ca_system_score_gemma":0.0001669744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001416845,"about_ca_topic_score_gemma":6.771378e-7,"domain_scores_codex":[0.9986433,0.00004700484,0.0002956303,0.0002708727,0.0004637233,0.0002794556],"domain_scores_gemma":[0.9990111,0.00002882557,0.0001609977,0.0004403603,0.000194953,0.0001637718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001673445,0.002858936,0.2329339,0.001806744,0.007737342,0.00009532032,0.001555978,0.000004024158,0.728523,0.00008671825,0.009746822,0.01297785],"study_design_scores_gemma":[0.004587471,0.00107208,0.003432384,0.0007006461,0.0002312026,0.00001171146,0.0001592383,0.0001815268,0.9888253,0.00009484562,0.0005662001,0.0001373635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950714,0.001879348,0.000003011385,0.000286684,0.00001280959,0.00164872,0.0001276474,0.00002757275,0.0009427981],"genre_scores_gemma":[0.9976788,0.00004999261,0.0002468152,0.00002819102,0.00002152035,0.0000552321,0.0002102432,0.00002691566,0.001682268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2603024,"threshold_uncertainty_score":0.4804114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652993423138086,"score_gpt":0.2838673082085535,"score_spread":0.2673373739771726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}