{"id":"W2921856972","doi":"10.1111/acel.12928","title":"Increased intron retention is a post‐transcriptional signature associated with progressive aging and Alzheimer’s disease","year":2019,"lang":"en","type":"article","venue":"Aging Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Temasek Life Sciences Laboratory; Ministry of Education - Singapore","keywords":"Biology; Intron; Disease; Signature (topology); Genetics; Alzheimer's disease; Gene; Computational biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131399,0.00018227,0.0001918772,0.0003832929,0.0001090137,0.0001618614,0.0001054623,0.0001750569,0.0005479055],"category_scores_gemma":[0.0001453758,0.00009192435,0.0001383456,0.0002862268,0.0001597173,0.000105928,0.0001031953,0.0002114851,0.0001941948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007568698,"about_ca_system_score_gemma":0.00008206083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002524872,"about_ca_topic_score_gemma":0.0003523724,"domain_scores_codex":[0.9999187,0.000009385248,0.00001028539,0.00002894954,0.00002086772,0.00001182384],"domain_scores_gemma":[0.9997391,0.00002075926,0.0001727888,0.00001362392,0.00002481683,0.00002888147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002770418,0.00003203919,0.0261005,0.00006058352,0.00003200047,0.0004562126,0.00007442212,0.00003776216,0.9677353,0.00009962087,0.0001164021,0.004978213],"study_design_scores_gemma":[0.0000170114,0.0004622537,0.8807774,0.00001985342,0.0001021367,0.004127549,0.0001146478,0.0005812143,0.110471,0.0004331267,0.00287965,0.00001416852],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953889,0.001866801,0.001833213,0.00003405352,0.00001213123,0.000007552622,0.0003165575,0.00004120083,0.0004996332],"genre_scores_gemma":[0.9966271,0.000673577,0.001264669,0.00005357042,0.0000180368,0.0000105243,0.0006005396,0.00001234695,0.0007396822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005479055,"threshold_uncertainty_score":0.001832962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006837384285640304,"score_gpt":0.2331291357915745,"score_spread":0.2262917515059343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}