{"id":"W2921856972","doi":"10.1111/acel.12928","title":"Increased intron retention is a post‐transcriptional signature associated with progressive aging and Alzheimer’s disease","year":2019,"lang":"en","type":"article","venue":"Aging Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Temasek Life Sciences Laboratory; Ministry of Education - Singapore","keywords":"Biology; Intron; Disease; Signature (topology); Genetics; Alzheimer's disease; Gene; Computational biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001290451,0.0001176573,0.00008877503,0.00003936826,0.00007840739,0.00004840578,0.00007928493,0.00006908653,0.00003683943],"category_scores_gemma":[0.00002235635,0.00009910716,0.00004282962,0.00006176368,0.00004358407,0.00001026218,0.00004044758,0.0001374774,0.000005897036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001181243,"about_ca_system_score_gemma":0.00007742191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003863051,"about_ca_topic_score_gemma":0.000007154137,"domain_scores_codex":[0.9991214,0.00005864442,0.0000843606,0.0003095157,0.0001824976,0.0002435731],"domain_scores_gemma":[0.9995282,0.00001212754,0.00005644598,0.000153255,0.0001112437,0.0001386745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001911803,0.00004886548,0.05369984,0.00003132932,0.00008767969,0.00001806293,0.00005893913,0.00001207485,0.9451041,0.00001281774,0.0003283737,0.0004066894],"study_design_scores_gemma":[0.007372569,0.001609918,0.528959,0.0006985024,0.0004268709,0.00002587649,0.000547746,0.005843279,0.4495368,0.0001388081,0.003631605,0.00120899],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950762,0.003946582,0.00005607019,0.0004117479,0.00002675998,0.0002528879,0.00002984979,0.00001488241,0.0001849634],"genre_scores_gemma":[0.9979922,0.00004186767,0.0001081103,0.0004676343,0.00005789412,0.00001134165,0.0004280963,0.0000188592,0.0008739928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4955674,"threshold_uncertainty_score":0.4041473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006837384285640304,"score_gpt":0.2331291357915745,"score_spread":0.2262917515059343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}