{"id":"W2921862595","doi":"10.1080/21505594.2019.1596505","title":"The mitochondrial thiamine pyrophosphate transporter TptA promotes adaptation to low iron conditions and virulence in fungal pathogen <i>Aspergillus fumigatus</i>","year":2019,"lang":"en","type":"article","venue":"Virulence","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; Society of the Friendly Sons of St. Patrick for the Relief of Emigrants from Ireland","keywords":"Aspergillus fumigatus; Biology; Virulence; Microbiology; Siderophore; Insertional mutagenesis; ATP-binding cassette transporter; Mutant; Pathogen; Virulence factor; Gene; Biochemistry; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008493714,0.0003128645,0.0002635783,0.0001555853,0.0001394552,0.0003434761,0.0001826804,0.0002349601,0.0008757815],"category_scores_gemma":[0.0001107053,0.00013378,0.0002926337,0.0001261471,0.0001584598,0.0001241892,0.0002899836,0.000436629,0.0003627171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003288309,"about_ca_system_score_gemma":0.0001990459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00284904,"about_ca_topic_score_gemma":0.002708866,"domain_scores_codex":[0.9998816,0.00001424156,0.00001469782,0.00002771851,0.00002900196,0.00003282006],"domain_scores_gemma":[0.999868,0.00001446506,0.00004124187,0.00001347446,0.00002140243,0.00004135894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003959961,0.000009895078,0.0003396494,0.0000150673,0.000002916092,0.00004872759,0.000008079178,0.00001664206,0.9990962,0.00002628596,0.00003200021,0.0003651604],"study_design_scores_gemma":[0.00001482094,0.0001948074,0.0364915,0.00001802047,0.00003590322,0.0005730446,0.0001177071,0.001623699,0.9575976,0.00004743883,0.003275312,0.00001012758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964498,0.0008718746,0.001295419,0.00009606883,0.00002631325,0.0000120093,0.0002933296,0.0001016177,0.0008534843],"genre_scores_gemma":[0.9976496,0.0002421551,0.0004966772,0.00004028912,0.000004665227,0.000007457444,0.0003791216,0.00001789611,0.001162217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00284904,"threshold_uncertainty_score":0.005664945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005366458765754511,"score_gpt":0.2296373303124928,"score_spread":0.2242708715467383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}