{"id":"W2921862595","doi":"10.1080/21505594.2019.1596505","title":"The mitochondrial thiamine pyrophosphate transporter TptA promotes adaptation to low iron conditions and virulence in fungal pathogen <i>Aspergillus fumigatus</i>","year":2019,"lang":"en","type":"article","venue":"Virulence","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; Society of the Friendly Sons of St. Patrick for the Relief of Emigrants from Ireland","keywords":"Aspergillus fumigatus; Biology; Virulence; Microbiology; Siderophore; Insertional mutagenesis; ATP-binding cassette transporter; Mutant; Pathogen; Virulence factor; Gene; Biochemistry; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001765918,0.0001711841,0.0001281061,0.00004369789,0.0001305779,0.00005705997,0.0002743367,0.0001183728,0.00003067946],"category_scores_gemma":[0.00005258097,0.0001331735,0.00004677535,0.0001712342,0.0001258298,0.00001198813,0.00009769286,0.0001532422,0.00008162791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001448516,"about_ca_system_score_gemma":0.00008094859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007426187,"about_ca_topic_score_gemma":0.0002552556,"domain_scores_codex":[0.9985948,0.00007016905,0.0002312993,0.0004789608,0.0002517748,0.0003730135],"domain_scores_gemma":[0.9993465,0.0000332805,0.00004447443,0.0003591649,0.00008398612,0.0001326002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002346362,0.00004478785,0.002530704,0.00002882246,0.000008182731,0.000007515277,0.0002119713,0.000349265,0.9930068,0.00005648748,0.00009298213,0.003427859],"study_design_scores_gemma":[0.001663608,0.001398366,0.05197624,0.0001615215,0.00001843766,0.00002347504,0.0003783907,0.002520634,0.9277004,0.0003094084,0.01324564,0.0006038707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969027,0.001189739,0.0002156817,0.0004254428,0.0002741501,0.0006242351,0.0001562104,0.000009338653,0.0002025148],"genre_scores_gemma":[0.9972839,0.0008423208,0.0003873686,0.0002551257,0.0001271485,0.00008438851,0.00008033073,0.00002093286,0.0009185047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06530638,"threshold_uncertainty_score":0.5430657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005366458765754511,"score_gpt":0.2296373303124928,"score_spread":0.2242708715467383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}