{"id":"W2921870084","doi":"10.1016/j.stem.2019.02.013","title":"Close Quarters Can Be a Good Fit for Stem Cells to Become T Cells","year":2019,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Biology; Mesoderm; Stem cell; Induced pluripotent stem cell; Cell biology; Haematopoiesis; Stromal cell; Mesenchymal stem cell; Organoid; Embryonic stem cell; Cell; Immunology; Genetics; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.0008736062,0.001485985,0.002493602,0.0009036984,0.0001987449,0.0002595027,0.001394239,0.002092037,0.003358914],"category_scores_gemma":[0.000003789231,0.001438114,0.001361642,0.0006050519,0.0001395749,0.00008838291,0.0003323316,0.00330243,0.003341259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001253678,"about_ca_system_score_gemma":0.0008962809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003036395,"about_ca_topic_score_gemma":0.00005529559,"domain_scores_codex":[0.9914331,0.0003459391,0.001330324,0.002349305,0.001906335,0.002634936],"domain_scores_gemma":[0.9936618,0.001319713,0.0005391194,0.003176431,0.0004829614,0.0008199473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004018686,0.0002501151,0.00002308199,0.005525825,0.000188569,0.0006504068,0.001232398,0.00001998543,0.2040105,0.000001295273,0.7853894,0.002306468],"study_design_scores_gemma":[0.003370309,0.001921074,0.000002029653,0.0002575908,0.0003411889,0.00002279612,0.0004056786,0.00006312614,0.2921923,0.000003964793,0.7004144,0.001005552],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.1689149,0.003315438,0.0003971401,0.6351504,0.0172155,0.04844857,0.007537831,0.001149317,0.1178709],"genre_scores_gemma":[0.00405548,0.0001588217,0.0003414581,0.2710383,0.004392914,0.0005991797,0.0005623367,0.0007200912,0.7181314],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.6002606,"threshold_uncertainty_score":0.9997889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04010783111700474,"score_gpt":0.2876726499778411,"score_spread":0.2475648188608364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}