{"id":"W2921875038","doi":"10.1038/s41598-019-40330-1","title":"TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Dalhousie University; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation; Beatrice Hunter Cancer Research Institute","keywords":"PTEN; Cancer; Cancer research; Protein kinase B; Cancer cell; TRPM2; Downregulation and upregulation; Metastasis; Gene silencing; Biology; Transient receptor potential channel; PI3K/AKT/mTOR pathway; Medicine; Signal transduction; Internal medicine; Receptor; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135367,0.0002519495,0.0002456883,0.0001864006,0.0001427338,0.000265954,0.0001201794,0.0002755396,0.001300196],"category_scores_gemma":[0.00009059336,0.00007380344,0.0002727351,0.0001307258,0.0002253869,0.0003144308,0.0001892625,0.0006934729,0.0002676736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002030112,"about_ca_system_score_gemma":0.0002544146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004358551,"about_ca_topic_score_gemma":0.0005935446,"domain_scores_codex":[0.9999025,0.00001452242,0.000007096047,0.00001327612,0.00002550457,0.00003701792],"domain_scores_gemma":[0.999969,0.000002211905,0.000007757466,0.000002969729,0.000004951071,0.00001306667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006084206,0.0001012574,0.0005132232,0.00009733577,0.00001065789,0.00008258787,0.00001813293,0.00008457202,0.9957071,0.0001638315,0.0002854115,0.002327519],"study_design_scores_gemma":[0.0001874326,0.001323421,0.02113421,0.00001846738,0.00007726201,0.0005798418,0.0001736761,0.00335484,0.9640849,0.0003697167,0.008681407,0.00001487318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928404,0.002843888,0.001394686,0.000398615,0.00008095277,0.00001948617,0.0002145912,0.0001391128,0.002068324],"genre_scores_gemma":[0.9963529,0.001171856,0.0004761218,0.00007838263,0.00001690911,0.00002708253,0.0001613527,0.000008712736,0.001706663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300196,"threshold_uncertainty_score":0.00434953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02893393954953054,"score_gpt":0.2445993756903556,"score_spread":0.2156654361408251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}