{"id":"W2921875038","doi":"10.1038/s41598-019-40330-1","title":"TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Dalhousie University; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation; Beatrice Hunter Cancer Research Institute","keywords":"PTEN; Cancer; Cancer research; Protein kinase B; Cancer cell; TRPM2; Downregulation and upregulation; Metastasis; Gene silencing; Biology; Transient receptor potential channel; PI3K/AKT/mTOR pathway; Medicine; Signal transduction; Internal medicine; Receptor; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008127562,0.0001678472,0.0001605318,0.0001017116,0.000713804,0.0003903038,0.0001620842,0.00004948595,0.0001355599],"category_scores_gemma":[0.0003097829,0.00009987203,0.0000685515,0.0007670496,0.0002484533,0.0004195562,0.0001026629,0.0001444047,0.00003420357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003293953,"about_ca_system_score_gemma":0.0001348886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001496104,"about_ca_topic_score_gemma":0.00002346293,"domain_scores_codex":[0.9976895,0.0001047194,0.0003798339,0.0008966501,0.0005909663,0.000338343],"domain_scores_gemma":[0.9990277,0.000084656,0.0003488305,0.0003282106,0.0001343471,0.00007623969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006073294,0.00004407208,0.0008092567,0.00003892271,0.000002212848,0.00004383193,0.002617928,0.0001978717,0.9931147,0.0001257882,0.002711946,0.0002874341],"study_design_scores_gemma":[0.00009233531,0.00004573788,0.00007237696,0.00008455391,0.000006380008,0.0002264607,0.0002855433,0.0006214938,0.9886802,0.005274395,0.004458899,0.0001516248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866239,0.0002037641,0.00008543364,0.0009890071,0.01098206,0.0006535279,0.000004122074,0.0000635278,0.000394698],"genre_scores_gemma":[0.9958748,0.0000238342,0.00003147572,0.0001724475,0.0001896965,0.00004388862,0.000006502182,0.00001749416,0.003639855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01079236,"threshold_uncertainty_score":0.5490076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02893393954953054,"score_gpt":0.2445993756903556,"score_spread":0.2156654361408251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}