{"id":"W2921911282","doi":"10.1200/jco.2019.37.7_suppl.429","title":"Avelumab treatment in metastatic urothelial carcinoma: Association between early response and durable outcomes in the phase Ib JAVELIN Solid Tumor Study.","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Avelumab; Medicine; Metastatic Urothelial Carcinoma; Javelin; Internal medicine; Response Evaluation Criteria in Solid Tumors; Oncology; Chemotherapy; Urothelial carcinoma; Phases of clinical research; Immunotherapy; Cancer; Pembrolizumab; Bladder cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001935852,0.0002235302,0.0005762884,0.0002761706,0.00024837,0.0007993871,0.0003588363,0.0003803866,0.0009326933],"category_scores_gemma":[0.00141401,0.0002183028,0.0009079661,0.0004493741,0.0001862116,0.000379299,0.0003826954,0.0005969751,0.0001796283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003630467,"about_ca_system_score_gemma":0.0003899147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006207314,"about_ca_topic_score_gemma":0.001339508,"domain_scores_codex":[0.9993948,0.0003169542,0.00005170679,0.0001024848,0.00007499832,0.00005905731],"domain_scores_gemma":[0.9984183,0.0003225731,0.0006866076,0.0001242882,0.00009511684,0.0003530242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.07896306,0.001088428,0.8945349,0.000311623,0.001713128,0.0001308512,0.00009435762,0.0003690324,0.004836033,0.00007265847,0.000873605,0.01701234],"study_design_scores_gemma":[0.005720522,0.01510922,0.9733726,0.00005013455,0.001148161,0.0005071374,0.0000828835,0.0009716395,0.001082548,0.00007281592,0.001867345,0.00001501476],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970239,0.001799527,0.00009380456,0.00006224428,0.00001053287,0.00006423629,0.0005636316,0.000006181743,0.0003758923],"genre_scores_gemma":[0.9981053,0.0003241255,0.000135337,0.00004803849,0.00002092273,0.00004036341,0.001070425,0.000003687114,0.0002517109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001935852,"threshold_uncertainty_score":0.01023787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1100972776875807,"score_gpt":0.4788035239572756,"score_spread":0.3687062462696949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}