{"id":"W2921930118","doi":"10.1176/appi.ajp.2018.18070824","title":"Cariprazine Treatment of Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Phase 3 Study","year":2019,"lang":"en","type":"article","venue":"American Journal of Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Placebo; Tolerability; Internal medicine; Psychology; Partial agonist; Medicine; Adverse effect; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002910563,0.001528785,0.003158492,0.0006360275,0.000760505,0.0009225356,0.001054444,0.002225755,0.006125936],"category_scores_gemma":[0.001888677,0.0008661093,0.001732178,0.0004928857,0.001219772,0.0007873087,0.000318072,0.002080373,0.0009793675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006421828,"about_ca_system_score_gemma":0.001747333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001076594,"about_ca_topic_score_gemma":0.002887157,"domain_scores_codex":[0.99911,0.0004671812,0.00005944665,0.0001342595,0.0000987988,0.0001302691],"domain_scores_gemma":[0.9988673,0.000299097,0.0002564245,0.0001047018,0.00011006,0.0003625799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9428366,0.02461967,0.0006397015,0.001054015,0.0008749128,0.00007743375,0.00008545074,0.0002384429,0.00792607,0.00008769875,0.001066497,0.02049345],"study_design_scores_gemma":[0.9449188,0.05286265,0.001286002,0.00002153241,0.0001610306,0.00002527801,0.000008213803,0.000140193,0.0002467636,0.00003477593,0.0002854245,0.000009364941],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713434,0.005790898,0.001623555,0.000777368,0.0006176344,0.01626281,0.001689344,0.0003037024,0.001591323],"genre_scores_gemma":[0.9622164,0.005192128,0.004346456,0.002248285,0.0008508726,0.0205139,0.001520916,0.0000614843,0.003049604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006125936,"threshold_uncertainty_score":0.02049327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367280888067106,"score_gpt":0.3243013161529713,"score_spread":0.3106285072723002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}