{"id":"W2921973674","doi":"10.1038/s41467-019-09037-9","title":"Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Celiac Disease Research and Management","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Health Sciences","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Research Executive Agency; Canadian Institutes of Health Research; McMaster University; Boehringer Ingelheim Stiftung; Crohn's and Colitis Foundation; Crohn's and Colitis Foundation of America","keywords":"Proteases; Elastase; Gluten; Immune system; Protease; Biology; Pseudomonas aeruginosa; Inflammation; Antigen; Microbiology; Immunology; Proteolytic enzymes; Enzyme; Biochemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003109277,0.0002004411,0.000316225,0.000117566,0.0002031333,0.00005378581,0.0003580627,0.0001889679,0.0002294396],"category_scores_gemma":[0.0004291139,0.0001767586,0.0001369279,0.0004362987,0.00009225064,0.0002680891,0.0006993292,0.000876813,0.0003731012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001604959,"about_ca_system_score_gemma":0.0002222299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001666826,"about_ca_topic_score_gemma":0.0001721206,"domain_scores_codex":[0.9983962,0.0003033352,0.0001810317,0.0003516065,0.0004076551,0.0003602302],"domain_scores_gemma":[0.9970291,0.0001605792,0.00007779587,0.002205082,0.0002624276,0.0002650187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001449131,0.0009062312,0.006440755,0.0001720437,0.0002142803,0.00001930031,0.0001508738,0.000003042371,0.9713635,0.0001934893,0.008202771,0.01088453],"study_design_scores_gemma":[0.002766271,0.0009039947,0.4074883,0.000552336,0.0001602852,0.00004510859,0.0001413535,0.0008691244,0.1794107,0.00008453755,0.4068924,0.0006854559],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759917,0.0002921384,0.0000774741,0.01459052,0.0001857305,0.004418981,0.0000849305,0.000157068,0.004201454],"genre_scores_gemma":[0.9928361,0.0002538694,0.004810292,0.0006023464,0.000137937,0.0002908226,0.0002930326,0.00003144141,0.0007442106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7919528,"threshold_uncertainty_score":0.7208006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03511808544730753,"score_gpt":0.3464862813906808,"score_spread":0.3113681959433733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}