{"id":"W2922010013","doi":"10.1186/s12864-019-5592-6","title":"Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus","year":2019,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Helminth infection and control","field":"Veterinary","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Biotechnology and Biological Sciences Research Council; University of Glasgow; Directorate for Biological Sciences; Royal Society; Scottish Government; Rural and Environment Science and Analytical Services Division; Wellcome Trust","keywords":"Biology; Haemonchus contortus; Quantitative trait locus; Genetics; Population; Locus (genetics); Ivermectin; Genetic variation; Evolutionary biology; Nematode; Gene; Zoology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004623312,0.0001757863,0.0002849516,0.0001140493,0.000164006,0.00006237222,0.0001458957,0.00009166791,0.0000198919],"category_scores_gemma":[0.0000441221,0.0001579558,0.0001295983,0.0001134565,0.00002394949,0.0001225454,0.0000358771,0.0001242235,0.00002877037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002637214,"about_ca_system_score_gemma":0.00006800445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003764424,"about_ca_topic_score_gemma":0.001450573,"domain_scores_codex":[0.9986261,0.0001853654,0.0004270807,0.0003659194,0.0001164228,0.0002790763],"domain_scores_gemma":[0.999114,0.0002737505,0.0001823893,0.0003253296,0.00005507448,0.00004948829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0140572,0.001101732,0.2971594,0.00166481,0.0004750463,0.0001182514,0.01691684,0.08125318,0.5656652,0.01325549,0.003690551,0.004642304],"study_design_scores_gemma":[0.009293679,0.0005946073,0.5168968,0.0001835412,0.0003875193,0.0002965161,0.00321943,0.4356199,0.0003540484,0.01687802,0.01475879,0.001517216],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883964,0.001444284,0.008054356,0.0001002773,0.0001869026,0.001124988,0.00004617098,0.00003988813,0.0006067501],"genre_scores_gemma":[0.9933035,0.00001944478,0.005473811,0.0001770556,0.0001357567,0.0000983372,0.00004819718,0.00002950418,0.0007143702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5653111,"threshold_uncertainty_score":0.6441251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07920461040840107,"score_gpt":0.3119305012975506,"score_spread":0.2327258908891495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}