{"id":"W2922021164","doi":"10.1126/science.aat4042","title":"Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Complementary and Integrative Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; American Cancer Society; Canadian Institutes of Health Research; Pew Charitable Trusts; National Institutes of Health; National Science Foundation","keywords":"Endocytosis; Cell biology; Biology; Immune system; Segmented filamentous bacteria; CDC42; Antigen; Microbiology; Cell; Clostridia; Immunology; Bacteria; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577577,0.0002926239,0.0002494346,0.0002595596,0.0003864079,0.0008049012,0.000142501,0.0005229356,0.001516012],"category_scores_gemma":[0.0001491795,0.0001891039,0.0002455328,0.0001259756,0.000363553,0.000394712,0.0004062899,0.000781972,0.0009390595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005522651,"about_ca_system_score_gemma":0.0003152268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004419563,"about_ca_topic_score_gemma":0.0007699486,"domain_scores_codex":[0.9997916,0.00003864661,0.000009162058,0.00003981931,0.00005149563,0.0000693637],"domain_scores_gemma":[0.9999,0.000005396347,0.0000186574,0.000008286104,0.00002601384,0.00004161454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006909109,0.00005638478,0.002675039,0.0001181926,0.00001730168,0.0004104856,0.00009876188,0.0001120176,0.9730923,0.001459969,0.002587326,0.01868142],"study_design_scores_gemma":[0.0001533507,0.0007882884,0.1402593,0.0001172294,0.00008525727,0.001622289,0.001079254,0.004575417,0.7745814,0.003487731,0.0731995,0.00005092609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9243477,0.04088892,0.00609024,0.005233149,0.001018781,0.00005048484,0.0004835295,0.0004300682,0.02145704],"genre_scores_gemma":[0.9826288,0.007031732,0.001112351,0.0004583809,0.0001589722,0.00001564548,0.0001401429,0.00004658274,0.008407351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001516012,"threshold_uncertainty_score":0.00507158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005602837585625205,"score_gpt":0.2360317339933365,"score_spread":0.2304288964077112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}