{"id":"W2922063178","doi":"10.1093/annonc/mdx440.048","title":"Adjuvant therapy with nivolumab (NIVO) versus ipilimumab (IPI) after complete resection of stage III/IV melanoma: A randomized, double-blind, phase 3 trial (CheckMate 238)","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Ipilimumab; Internal medicine; Nivolumab; Hazard ratio; Clinical endpoint; Population; Melanoma; Stage (stratigraphy); Randomized controlled trial; Oncology; Gastroenterology; Surgery; Cancer; Confidence interval; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001148666,0.001297074,0.002305897,0.0003358691,0.0003291709,0.0008745223,0.0008128975,0.001281134,0.005194264],"category_scores_gemma":[0.0009683496,0.0005201988,0.001553933,0.0003012998,0.00090937,0.0008851662,0.0003456365,0.002962299,0.0009514594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000728698,"about_ca_system_score_gemma":0.001106359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001169019,"about_ca_topic_score_gemma":0.002857303,"domain_scores_codex":[0.9997218,0.0001216306,0.00001224445,0.00006677872,0.00001668282,0.00006084274],"domain_scores_gemma":[0.9994316,0.0001575692,0.0001106658,0.00004846069,0.00002256623,0.0002291695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9635579,0.006403876,0.0004678897,0.0004847762,0.0005765572,0.00002232404,0.0000459004,0.0006217032,0.003489421,0.0001044147,0.001086989,0.02313833],"study_design_scores_gemma":[0.9255592,0.07091315,0.001317935,0.00003006662,0.0003490468,0.00002410765,0.00001764953,0.000588269,0.0005309826,0.0001383822,0.0005174045,0.00001378363],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915087,0.003118745,0.0005493683,0.0005015828,0.0004798629,0.001347973,0.0007175775,0.0001442442,0.001631954],"genre_scores_gemma":[0.9886614,0.002107512,0.001414335,0.000859559,0.0003284424,0.00201575,0.00102514,0.000039642,0.003548176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005194264,"threshold_uncertainty_score":0.0173766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2474911193051816,"score_gpt":0.4682165581798732,"score_spread":0.2207254388746916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}