{"id":"W2922072900","doi":"10.1128/mbio.00152-19","title":"Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes","year":2019,"lang":"en","type":"article","venue":"mBio","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Government of Canada; McGill University","keywords":"Pre-replication complex; Biology; Control of chromosome duplication; Helicase; DNA replication; Genome; Viral replication; Origin recognition complex; Replication (statistics); Eukaryotic DNA replication; Genetics; DNA; Cell biology; Virology; Virus; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196151,0.0002271529,0.0001353497,0.0001257129,0.0001912872,0.0003085754,0.0001253926,0.0001712323,0.001231669],"category_scores_gemma":[0.000177055,0.0001313987,0.0002457682,0.00005439773,0.000117075,0.0002014063,0.0003589243,0.0003187924,0.0004794777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000203804,"about_ca_system_score_gemma":0.0001894486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004898818,"about_ca_topic_score_gemma":0.0006057786,"domain_scores_codex":[0.9998155,0.00003349952,0.00001286334,0.00004200563,0.00004453674,0.00005150384],"domain_scores_gemma":[0.999907,0.00001738967,0.0000205204,0.00001154293,0.00001087676,0.00003268302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001201056,0.0000421877,0.0006246137,0.00003813101,0.000007051779,0.00005338836,0.00002433624,0.0000273381,0.9970952,0.0002441454,0.00005826063,0.001665253],"study_design_scores_gemma":[0.000009739957,0.0001317877,0.006780739,0.000008065749,0.000009915366,0.0001999595,0.0000282869,0.001029911,0.9888102,0.00005636004,0.002931157,0.000003855015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935279,0.001645348,0.002874941,0.00006921471,0.0000204406,0.00001315592,0.00006910699,0.00004663121,0.001733243],"genre_scores_gemma":[0.9975055,0.000302522,0.0007376818,0.00001532586,0.000004008014,0.000007538744,0.0001006298,0.000006836626,0.001319874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231669,"threshold_uncertainty_score":0.00412035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009266174958459323,"score_gpt":0.2496189580527287,"score_spread":0.2403527830942694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}