{"id":"W2922072900","doi":"10.1128/mbio.00152-19","title":"Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes","year":2019,"lang":"en","type":"article","venue":"mBio","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Government of Canada; McGill University","keywords":"Pre-replication complex; Biology; Control of chromosome duplication; Helicase; DNA replication; Genome; Viral replication; Origin recognition complex; Replication (statistics); Eukaryotic DNA replication; Genetics; DNA; Cell biology; Virology; Virus; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192394,0.00007749815,0.00009174615,0.00002127293,0.0000345258,0.000005142063,0.00013436,0.00006201437,0.00003517329],"category_scores_gemma":[0.00001627974,0.00005312514,0.00006457388,0.00005898088,0.00004880769,0.000004615451,0.00006760885,0.00004955591,0.000005148476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001257611,"about_ca_system_score_gemma":0.00002881423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004388009,"about_ca_topic_score_gemma":0.00002505496,"domain_scores_codex":[0.9993949,0.00004555846,0.0001478664,0.0002281374,0.0001062592,0.00007727191],"domain_scores_gemma":[0.9991316,0.000005394618,0.0001679046,0.0005970004,0.00008189743,0.00001623447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000509355,0.00006731559,0.005287248,0.00001810846,0.00003762818,1.267825e-7,0.00004074993,0.0000101125,0.9929059,0.0004384102,0.0000415185,0.001101966],"study_design_scores_gemma":[0.0002324462,0.0003761431,0.005085108,0.00001961043,0.0000144327,0.00001477689,0.00004529132,0.00002346882,0.9903961,0.0002055139,0.003520949,0.00006619357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975917,0.0000965364,0.00004266793,0.0000583266,0.00007630909,0.0002532518,0.00001298444,0.000009174699,0.001859041],"genre_scores_gemma":[0.998033,0.00001000265,0.0002099321,0.00003257623,0.00003682665,0.00001431812,0.00004157905,0.00001192602,0.001609858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00347943,"threshold_uncertainty_score":0.216638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009266174958459323,"score_gpt":0.2496189580527287,"score_spread":0.2403527830942694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}