{"id":"W2922099376","doi":"10.1111/jdv.15400","title":"Efficacy of tildrakizumab for moderate‐to‐severe plaque psoriasis: pooled analysis of three randomized controlled trials at weeks 12 and 28","year":2019,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Probity Medical Research","funders":"Merck","keywords":"Medicine; Placebo; Psoriasis; Internal medicine; Psoriasis Area and Severity Index; Randomized controlled trial; Gastroenterology; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03360318,0.003009013,0.01977522,0.003468978,0.0004325804,0.003617818,0.001478157,0.002417399,0.003704441],"category_scores_gemma":[0.03468229,0.001498602,0.02986229,0.003833437,0.0008858214,0.001518214,0.001384623,0.001810563,0.0003725775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001466467,"about_ca_system_score_gemma":0.001998331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001754523,"about_ca_topic_score_gemma":0.003156516,"domain_scores_codex":[0.9710644,0.01804599,0.005440257,0.002635711,0.002207636,0.0006059303],"domain_scores_gemma":[0.9792649,0.0105651,0.006830377,0.001371915,0.001418159,0.0005496134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.2006766,0.000229148,0.003863237,0.05405724,0.7159211,0.00007744953,0.00009417319,0.0007452721,0.0009495181,0.0001084574,0.001010368,0.02226746],"study_design_scores_gemma":[0.1311897,0.005567553,0.01424508,0.003339565,0.8413801,0.0001277589,0.00006672864,0.000590182,0.0005325148,0.0003932264,0.002481186,0.00008632817],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1208115,0.8612053,0.005644392,0.0008643285,0.001242193,0.004379343,0.003668351,0.0004119962,0.001772614],"genre_scores_gemma":[0.8069686,0.1709082,0.007094316,0.001538029,0.000740608,0.007974008,0.003594097,0.0001494771,0.001032692],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03360318,"threshold_uncertainty_score":0.1777127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02369100495985317,"score_gpt":0.2694269263587729,"score_spread":0.2457359213989197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}