{"id":"W2922126224","doi":"10.1158/0008-5472.can-18-3441","title":"Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto; Amgen (Canada); Alberta Children's Hospital; Canada's Michael Smith Genome Sciences Centre; Alberta Cancer Foundation; University of Calgary","funders":"Canadian Institutes of Health Research; Stand Up To Cancer; Medical Research Council; Wellcome; Royal Society; Cancer Research UK; Wellcome Trust","keywords":"Nonsynonymous substitution; Biology; Pediatric cancer; Somatic cell; Genome; Cancer; Genetics; Stem cell; Mutation; Somatic evolution in cancer; Progenitor cell; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002125547,0.0001333256,0.0001735461,0.000743862,0.0001770509,0.0003066053,0.0001438065,0.0001687507,0.000836651],"category_scores_gemma":[0.0005040008,0.00007738786,0.0001146826,0.0006121003,0.0002228517,0.0001389984,0.000259617,0.0002074768,0.0001312817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000238306,"about_ca_system_score_gemma":0.0001766648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001288388,"about_ca_topic_score_gemma":0.002242916,"domain_scores_codex":[0.9998302,0.00002430224,0.00001155541,0.00005752305,0.00004098124,0.00003538415],"domain_scores_gemma":[0.9997253,0.00007903281,0.0001168986,0.00002317302,0.00002422077,0.00003139223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000546071,0.00003761057,0.6491266,0.0001453764,0.0001362459,0.001476781,0.0003594634,0.001553057,0.3160113,0.0007036824,0.0003797094,0.02952407],"study_design_scores_gemma":[0.000006493129,0.0001147701,0.962734,0.00001941075,0.00007735452,0.004132751,0.0003049195,0.001928299,0.02784173,0.0007694364,0.002061703,0.000009125927],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981015,0.0003456793,0.0007549265,0.0000215976,0.000001197597,0.000003977133,0.0005078022,0.0000153933,0.0002478598],"genre_scores_gemma":[0.9985749,0.0002012728,0.0005310835,0.00001163032,0.00000205083,0.000005143632,0.0006031361,0.00001151355,0.00005937238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288388,"threshold_uncertainty_score":0.002798855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05154577427380286,"score_gpt":0.3664987135499801,"score_spread":0.3149529392761772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}