{"id":"W2922126224","doi":"10.1158/0008-5472.can-18-3441","title":"Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto; Amgen (Canada); Alberta Children's Hospital; Canada's Michael Smith Genome Sciences Centre; Alberta Cancer Foundation; University of Calgary","funders":"Canadian Institutes of Health Research; Stand Up To Cancer; Medical Research Council; Wellcome; Royal Society; Cancer Research UK; Wellcome Trust","keywords":"Nonsynonymous substitution; Biology; Pediatric cancer; Somatic cell; Genome; Cancer; Genetics; Stem cell; Mutation; Somatic evolution in cancer; Progenitor cell; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798413,0.00007094369,0.0001356791,0.0002617437,0.00003462179,0.00002051869,0.00003266229,0.00004472283,0.0004005678],"category_scores_gemma":[0.00002130045,0.00005790326,0.00002560645,0.0003929355,0.00004507375,0.00003225194,0.00005487121,0.0002070601,0.0001382745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001629055,"about_ca_system_score_gemma":0.0001649277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001852766,"about_ca_topic_score_gemma":0.0002923053,"domain_scores_codex":[0.9989448,0.00005119795,0.0001056689,0.0002591507,0.0003502777,0.0002889267],"domain_scores_gemma":[0.9995472,0.00006099358,0.00001223009,0.0001568522,0.00009081701,0.0001318752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002230223,0.0001414287,0.9906781,0.00007941194,0.00001341355,0.0001173175,0.00003100471,0.00002039645,0.005387554,0.00004476731,0.0009725266,0.002291111],"study_design_scores_gemma":[0.001783457,0.0004228096,0.9896055,0.00002865296,0.00001119298,0.00003404164,0.00002040838,0.00007268716,0.007433964,0.00005168875,0.0004838824,0.00005166351],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946491,0.003907219,4.714788e-7,0.000644047,0.0001001574,0.0003980019,0.000004636524,0.000009427687,0.0002869274],"genre_scores_gemma":[0.9984516,0.0009491058,0.00002957041,0.00005634378,0.0001978106,0.0001607689,0.000002837177,0.00001131846,0.0001406775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003802455,"threshold_uncertainty_score":0.4385937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05154577427380286,"score_gpt":0.3664987135499801,"score_spread":0.3149529392761772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}