{"id":"W2922140746","doi":"10.1158/1055-9965.epi-18-1083","title":"Intratumoral Sterol-27-Hydroxylase (<i>CYP27A1</i>) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer","year":2019,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Dana-Farber/Harvard Cancer Center; Queen's University Belfast; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation; Queen's University; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"CYP27A1; Prostate cancer; Calcitriol receptor; CYP24A1; Vitamin D and neurology; Internal medicine; Endocrinology; Cholesterol; Cerebrotendinous Xanthomatosis; Medicine; Cancer research; Liver X receptor; Cancer; Oncology; Biology; Biochemistry; Nuclear receptor; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203604,0.0001200043,0.0002148748,0.000360633,0.0001956803,0.0003808896,0.0001269351,0.0001569684,0.001033065],"category_scores_gemma":[0.0003173423,0.0001169905,0.0001920458,0.0004922032,0.0001895301,0.00008667949,0.000165053,0.0003027309,0.000159399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002565004,"about_ca_system_score_gemma":0.0001309007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002037098,"about_ca_topic_score_gemma":0.001911773,"domain_scores_codex":[0.9999043,0.00001741378,0.000004641681,0.00003740997,0.00001931928,0.00001696898],"domain_scores_gemma":[0.9996958,0.00004660927,0.0001427209,0.00002667138,0.00003074621,0.00005741891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009484029,0.00002274707,0.9778184,0.00001955759,0.00009727045,0.00007059327,0.00005259106,0.00008132919,0.0178071,0.00002208882,0.0001409039,0.002919081],"study_design_scores_gemma":[0.000006888153,0.00006425754,0.9972309,0.00000161984,0.00003859851,0.0002719275,0.00004830909,0.0001881305,0.001947683,0.00002973766,0.0001697185,0.000002258985],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999017,0.0003527442,0.00012997,0.00001894815,0.000001276725,0.000002418782,0.0002912823,0.000005872886,0.0001804435],"genre_scores_gemma":[0.9995623,0.00005813665,0.00004684934,0.000007764916,0.000002182054,0.000002364081,0.0001853882,0.000002167943,0.0001329163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002037098,"threshold_uncertainty_score":0.004050493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259672854831523,"score_gpt":0.2816105447416402,"score_spread":0.2690138161933249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}