{"id":"W2922140746","doi":"10.1158/1055-9965.epi-18-1083","title":"Intratumoral Sterol-27-Hydroxylase (<i>CYP27A1</i>) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer","year":2019,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Dana-Farber/Harvard Cancer Center; Queen's University Belfast; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation; Queen's University; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"CYP27A1; Prostate cancer; Calcitriol receptor; CYP24A1; Vitamin D and neurology; Internal medicine; Endocrinology; Cholesterol; Cerebrotendinous Xanthomatosis; Medicine; Cancer research; Liver X receptor; Cancer; Oncology; Biology; Biochemistry; Nuclear receptor; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001424467,0.0002472394,0.0004203864,0.0001261859,0.0000675285,0.00001919631,0.00008550383,0.0003186066,0.00002491265],"category_scores_gemma":[0.0002555663,0.000226571,0.00005562601,0.0001284436,0.00004673914,0.00004706349,0.00008173248,0.0001642947,0.000003714743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001432541,"about_ca_system_score_gemma":0.00009219816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001991812,"about_ca_topic_score_gemma":0.000595565,"domain_scores_codex":[0.9976982,0.000632102,0.000447296,0.0007050309,0.0001128889,0.0004044352],"domain_scores_gemma":[0.9990964,0.000135004,0.0003667683,0.0001865744,0.00007737973,0.0001378615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008621058,0.0000293093,0.472161,0.00008743123,0.0001064007,1.798061e-7,0.0001659109,0.0004226829,0.5168003,0.000009534954,0.001367395,0.007987691],"study_design_scores_gemma":[0.004459959,0.0006746407,0.8387267,0.001463739,0.0002423893,0.00001538265,0.0002498743,0.0008329113,0.1344411,0.0002711701,0.01777907,0.0008431144],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885155,0.00745345,0.0003156863,0.001080813,0.00168164,0.0008587574,0.0000482409,0.00001516605,0.00003076423],"genre_scores_gemma":[0.9937633,0.002818067,0.0007023542,0.0004317164,0.0009312748,0.0004690965,0.0000832349,0.00003311097,0.0007678013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3823593,"threshold_uncertainty_score":0.9239297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259672854831523,"score_gpt":0.2816105447416402,"score_spread":0.2690138161933249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}