{"id":"W2922171655","doi":"10.1016/j.redox.2019.101181","title":"Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress","year":2019,"lang":"en","type":"article","venue":"Redox Biology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Foundation Fighting Blindness","keywords":"Autophagy; Proteostasis; BAG3; Cell biology; Downregulation and upregulation; Biology; Unfolded protein response; Oxidative stress; Lysosome; Chemistry; Endoplasmic reticulum; Biochemistry; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003180296,0.0003185964,0.0007228177,0.0002337815,0.00005662598,0.000007417136,0.0001643242,0.0002779264,0.0005421122],"category_scores_gemma":[0.0002620807,0.0002773379,0.0001204158,0.0003569723,0.0002568545,0.00008315365,0.0001252357,0.0003120642,0.0001866583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916101,"about_ca_system_score_gemma":0.0007097983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002118859,"about_ca_topic_score_gemma":0.00001296736,"domain_scores_codex":[0.9976058,0.000751019,0.0003036158,0.0006717563,0.0001986732,0.0004691579],"domain_scores_gemma":[0.9979551,0.0009329121,0.0002160075,0.0003891669,0.0001990247,0.0003077284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02038212,0.00031675,0.001011137,0.00004186148,0.0003211924,0.00004104937,0.0004180621,0.00000939985,0.9747817,0.0002727008,0.00003179663,0.002372229],"study_design_scores_gemma":[0.00302017,0.005968223,0.1787971,0.00006244816,0.00006442542,0.0000175958,0.0000649241,0.0003025995,0.8112422,0.0001155585,0.000147577,0.0001972849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969402,0.0004295824,0.0001719408,0.0001470373,0.0001698625,0.001107021,0.0003064937,0.00007865705,0.0006492125],"genre_scores_gemma":[0.9985337,0.0001049726,0.0001543837,0.0004644295,0.00009916026,0.00005502704,0.00005917376,0.0000349999,0.0004941272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1777859,"threshold_uncertainty_score":0.9999679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0068011448189922,"score_gpt":0.2698645178659053,"score_spread":0.2630633730469131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}