{"id":"W2922225055","doi":"10.1016/j.ccell.2019.02.014","title":"Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer","year":2019,"lang":"en","type":"letter","venue":"Cancer Cell","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; American Cancer Society","keywords":"Methionine; Serine; Prostate cancer; Metabolism; Cancer research; Biology; Cancer; Biochemistry; Amino acid; Phosphorylation; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001013492,0.0005645805,0.0009219609,0.0003860474,0.001193398,0.001431098,0.0005679457,0.01296569,0.002867849],"category_scores_gemma":[0.003616376,0.0002641847,0.000441225,0.0002979673,0.001460748,0.00115929,0.0006446228,0.01021641,0.001406952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001481823,"about_ca_system_score_gemma":0.0008674705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001019442,"about_ca_topic_score_gemma":0.002333029,"domain_scores_codex":[0.9995826,0.0001298482,0.00004354368,0.00006483634,0.0001058233,0.00007344076],"domain_scores_gemma":[0.9987549,0.0007456058,0.00009731301,0.00006487391,0.0001323225,0.0002050938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009170111,0.0001110884,0.002262114,0.0001736291,0.00005354719,0.0120108,0.0001230104,0.000202677,0.005665166,0.01351457,0.9112944,0.053672],"study_design_scores_gemma":[0.000687542,0.0003417211,0.004418696,0.000244382,0.0001031966,0.01483918,0.0003800154,0.00108152,0.004272559,0.04786132,0.9256626,0.0001072883],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003386937,0.01103159,0.0003018057,0.9624185,0.01918315,0.00001375472,0.0001085841,0.00006911569,0.003486599],"genre_scores_gemma":[0.05574347,0.01815409,0.0008304715,0.7596198,0.1491837,0.0000763316,0.0001060894,0.00005469348,0.01623129],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01296569,"threshold_uncertainty_score":0.01075137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009768806604462499,"score_gpt":0.2523413375444232,"score_spread":0.2425725309399607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}