{"id":"W2922225055","doi":"10.1016/j.ccell.2019.02.014","title":"Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer","year":2019,"lang":"en","type":"letter","venue":"Cancer Cell","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; American Cancer Society","keywords":"Methionine; Serine; Prostate cancer; Metabolism; Cancer research; Biology; Cancer; Biochemistry; Amino acid; Phosphorylation; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002222323,0.0005383941,0.0007420511,0.00009166915,0.00005447407,0.00005286987,0.0002848128,0.0008248339,0.000361903],"category_scores_gemma":[0.00002298101,0.0005084573,0.0001612945,0.0001161217,0.000167976,0.00001278766,0.0002131427,0.0009577304,0.000007887927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009065998,"about_ca_system_score_gemma":0.0005630442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004076858,"about_ca_topic_score_gemma":0.001981374,"domain_scores_codex":[0.9975665,0.0001475944,0.0004154208,0.0009774191,0.0002488313,0.0006441893],"domain_scores_gemma":[0.9989384,0.00002956199,0.0002095013,0.0006076923,0.0001384183,0.00007645944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001440853,0.00003001639,0.0004499529,0.0009598038,0.0001326165,0.00001357596,0.0003606911,0.0001620511,0.07081896,0.000005669171,0.9212066,0.005715976],"study_design_scores_gemma":[0.001253497,0.00005877995,0.0004450869,0.00007245247,0.0001246531,0.000008914112,0.00006218756,0.000008443497,0.03616941,0.00002611937,0.9611619,0.0006085294],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.2410258,0.6339609,0.00001884226,0.1036287,0.0129626,0.001742291,0.001903379,0.00004838945,0.004709064],"genre_scores_gemma":[0.0170756,0.3079729,0.000457708,0.4091265,0.05494934,0.002168672,0.001829426,0.0004566662,0.2059632],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.325988,"threshold_uncertainty_score":0.9997367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009768806604462499,"score_gpt":0.2523413375444232,"score_spread":0.2425725309399607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}