{"id":"W2922246189","doi":"10.1186/s12977-019-0465-2","title":"Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages","year":2019,"lang":"en","type":"article","venue":"Retrovirology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; International AIDS Society; Jewish General Hospital","keywords":"Human immunodeficiency virus (HIV); Monocyte; Gene expression; Messenger RNA; Replication (statistics); Gene; Host (biology); Virology; Viral replication; Gene expression profiling; Antibody; Medicine; Biology; Computational biology; Bioinformatics; Cell biology; Genetics; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002232721,0.0001264537,0.0001691371,0.00007521557,0.00004569739,0.00001719051,0.0001772838,0.0002063195,0.000009899938],"category_scores_gemma":[0.00007933188,0.0001172534,0.00003047454,0.00006283544,0.00009002932,0.00001126732,0.0002202722,0.0001629189,0.00002733933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003128182,"about_ca_system_score_gemma":0.00005486014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003321012,"about_ca_topic_score_gemma":0.0000104054,"domain_scores_codex":[0.9987618,0.000114642,0.0001698164,0.0005399572,0.0001015762,0.0003122367],"domain_scores_gemma":[0.9992398,0.00001659855,0.00007538174,0.0005543604,0.00003502124,0.00007883652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002573034,0.00002141834,0.1218008,0.00002277275,0.000006109919,0.000007012931,0.00001530019,0.00003742496,0.8769318,0.000007942032,0.00003594078,0.0008560779],"study_design_scores_gemma":[0.0006090909,0.0003661363,0.2998672,0.000009345646,0.000001683867,0.00001601225,0.000006748727,0.0000848596,0.6983953,0.000008957881,0.0005410928,0.00009365248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979131,0.0008112667,0.0003433608,0.0002499943,0.00002252321,0.0004390935,0.000007640208,0.00001137771,0.0002015971],"genre_scores_gemma":[0.9970601,0.0004843763,0.001220794,0.0002702814,0.00004978464,0.00005912725,0.00006820624,0.00001794497,0.0007694533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1785366,"threshold_uncertainty_score":0.4781457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005783441608323798,"score_gpt":0.2430479984206227,"score_spread":0.2372645568122989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}