{"id":"W2922246189","doi":"10.1186/s12977-019-0465-2","title":"Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages","year":2019,"lang":"en","type":"article","venue":"Retrovirology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; International AIDS Society; Jewish General Hospital","keywords":"Human immunodeficiency virus (HIV); Monocyte; Gene expression; Messenger RNA; Replication (statistics); Gene; Host (biology); Virology; Viral replication; Gene expression profiling; Antibody; Medicine; Biology; Computational biology; Bioinformatics; Cell biology; Genetics; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988127,0.0002014432,0.0002284727,0.0001569794,0.0001620708,0.0002465787,0.00007894132,0.0001806215,0.001006577],"category_scores_gemma":[0.0001796521,0.0001008318,0.0001721855,0.000157487,0.0001880166,0.0001057705,0.0001304123,0.0003094618,0.0003364476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002174644,"about_ca_system_score_gemma":0.0001681675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004347846,"about_ca_topic_score_gemma":0.000614742,"domain_scores_codex":[0.9998291,0.0000383623,0.00001283673,0.00002240848,0.0000329701,0.00006425009],"domain_scores_gemma":[0.9998233,0.00007314694,0.00002183622,0.00001492213,0.00003484522,0.00003201565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004903313,0.00004681785,0.0007440174,0.00003951232,0.000003658876,0.00004586364,0.00003487652,0.00004590714,0.9973313,0.0000448983,0.00004091493,0.001132045],"study_design_scores_gemma":[0.00003303427,0.0007812604,0.01324141,0.000007980735,0.00001997448,0.0001548862,0.00007801964,0.0007055525,0.9836233,0.00005623517,0.001293252,0.000005117202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974133,0.001245466,0.0005561057,0.0000430537,0.00001404766,0.00001377371,0.0002175028,0.00002182463,0.0004750607],"genre_scores_gemma":[0.9959508,0.0007202127,0.00141957,0.00004737223,0.00001013502,0.000050552,0.0003066574,0.000009795588,0.001484911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006577,"threshold_uncertainty_score":0.003367305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005783441608323798,"score_gpt":0.2430479984206227,"score_spread":0.2372645568122989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}