{"id":"W2922269696","doi":"10.1111/cei.13290","title":"Mechanisms of human FoxP3+ Treg cell development and function in health and disease","year":2019,"lang":"en","type":"review","venue":"Clinical & Experimental Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre for Interdisciplinary Research in Rehabilitation; McGill University Health Centre","funders":"","keywords":"FOXP3; Immunology; Biology; Peripheral tolerance; Autoimmunity; Population; T cell; Immune tolerance; Regulatory T cell; IL-2 receptor; Cell biology; Antigen; Immune system; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004199421,0.0002519675,0.0003081274,0.0004695079,0.00008002701,0.0004156879,0.0002535289,0.0004200063,0.0008298311],"category_scores_gemma":[0.0001396034,0.0000720015,0.0001661132,0.0001957872,0.000253627,0.0002349749,0.0002326633,0.0004098303,0.000411727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003339979,"about_ca_system_score_gemma":0.000274023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003258351,"about_ca_topic_score_gemma":0.0002934763,"domain_scores_codex":[0.9998728,0.00002705738,0.00001590318,0.00002542921,0.00003260911,0.00002622021],"domain_scores_gemma":[0.9999429,0.00001582296,0.00001497764,0.000002815103,0.00001343177,0.0000100214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000391339,0.00007301514,0.004591517,0.004900197,0.0001011729,0.00173913,0.0002970161,0.0008103952,0.1942434,0.01195224,0.01162244,0.7692781],"study_design_scores_gemma":[0.0000716795,0.001214128,0.03218267,0.001331883,0.0003559758,0.01480537,0.0002511785,0.0009872185,0.08315114,0.009951695,0.8556364,0.00006064726],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01717242,0.9734431,0.003719638,0.0008804818,0.000244164,0.00002539775,0.0001121566,0.00008222579,0.004320453],"genre_scores_gemma":[0.2275316,0.7568532,0.003705856,0.001611093,0.001225156,0.0001058017,0.0004935513,0.00002352144,0.008450265],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0008298311,"threshold_uncertainty_score":0.002776086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08046621637234301,"score_gpt":0.3783418418044983,"score_spread":0.2978756254321553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}