{"id":"W2922269696","doi":"10.1111/cei.13290","title":"Mechanisms of human FoxP3+ Treg cell development and function in health and disease","year":2019,"lang":"en","type":"review","venue":"Clinical & Experimental Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre for Interdisciplinary Research in Rehabilitation; McGill University Health Centre","funders":"","keywords":"FOXP3; Immunology; Biology; Peripheral tolerance; Autoimmunity; Population; T cell; Immune tolerance; Regulatory T cell; IL-2 receptor; Cell biology; Antigen; Immune system; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0006452189,0.0006697852,0.003271918,0.0003668127,0.0002022576,0.00001290145,0.0003834314,0.00130051,0.0002543091],"category_scores_gemma":[0.00006805593,0.0005828951,0.0003542701,0.0001557848,0.00105431,0.00007526451,0.0007115018,0.001158883,0.0002785278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001456148,"about_ca_system_score_gemma":0.0006975309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007757932,"about_ca_topic_score_gemma":0.000008765456,"domain_scores_codex":[0.9942479,0.001423132,0.002510302,0.001085768,0.0000486327,0.0006842253],"domain_scores_gemma":[0.9976305,0.0004879569,0.001127073,0.0005995929,0.00003061203,0.0001242078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001127416,0.004907214,0.0002754579,0.009079362,0.001664223,0.00003988129,0.0009350498,5.516651e-8,0.1536986,0.009395602,0.0006699407,0.8182072],"study_design_scores_gemma":[0.00521664,0.004511863,0.0001603364,0.003118619,0.0003084792,0.00007603344,0.0008934183,1.529159e-7,0.01024146,0.0004651735,0.9741393,0.000868541],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02496081,0.972011,0.00001819747,0.00003707063,0.001666476,0.001076332,0.00002430599,0.00004728025,0.0001584973],"genre_scores_gemma":[0.04405493,0.9523194,0.00009768533,0.0002080452,0.00002230361,0.0001642486,0.0006381029,0.00007210294,0.002423202],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9734693,"threshold_uncertainty_score":0.999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08046621637234301,"score_gpt":0.3783418418044983,"score_spread":0.2978756254321553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}