{"id":"W2922394097","doi":"10.1038/s41419-019-1320-z","title":"LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway","year":2019,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Department of Education of Guizhou Province; Guizhou Medical University; Guizhou Science and Technology Department","keywords":"PI3K/AKT/mTOR pathway; Cancer research; Protein kinase B; Metastasis; Biology; Pancreatic cancer; Signal transduction; Cell growth; Cell cycle; Adenocarcinoma; Cancer; Apoptosis; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008107735,0.0001945998,0.0001350463,0.0001603974,0.0001960069,0.0002099586,0.0001086201,0.0001559226,0.0008598742],"category_scores_gemma":[0.00007597667,0.00006794697,0.000203163,0.000130809,0.0001414619,0.00013977,0.0001770407,0.0004902203,0.000219966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003288698,"about_ca_system_score_gemma":0.0002591758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008399552,"about_ca_topic_score_gemma":0.0009462941,"domain_scores_codex":[0.9999243,0.0000132635,0.000004548296,0.000007607989,0.00002180263,0.00002845102],"domain_scores_gemma":[0.999974,0.000002768657,0.000006553196,0.000002016778,0.000005177335,0.000009538245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003597058,0.00004880403,0.001895822,0.00008111714,0.0000116502,0.0002257257,0.00002679157,0.0001658395,0.9923396,0.000220746,0.0002594655,0.004364785],"study_design_scores_gemma":[0.00008491072,0.0005043002,0.06721419,0.00002557643,0.00008361639,0.001396159,0.0002100809,0.003947004,0.914461,0.0004422854,0.01161921,0.00001163609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918948,0.003686736,0.00151806,0.0001944287,0.0000210279,0.00001652795,0.0002626426,0.00006860419,0.002337109],"genre_scores_gemma":[0.9962082,0.001381768,0.0003432844,0.00005853412,0.000006283097,0.0000217262,0.0002778258,0.00000589343,0.001696402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008598742,"threshold_uncertainty_score":0.00287658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01833519586001991,"score_gpt":0.2805528866739551,"score_spread":0.2622176908139351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}