{"id":"W2922406744","doi":"10.1002/stem.3004","title":"Concise Review: Targeting Cancer Stem Cells and Their Supporting Niche Using Oncolytic Viruses","year":2019,"lang":"en","type":"review","venue":"Stem Cells","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Foundation; Ontario Institute for Cancer Research","keywords":"Biology; Oncolytic virus; Cancer stem cell; Cancer research; Chimeric antigen receptor; Immune system; Tumor microenvironment; Cancer cell; Antigen; Cancer; Metastasis; Stem cell; Immunotherapy; Immunology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003505452,0.001027957,0.0008772709,0.001460476,0.0001917742,0.0008881315,0.0006811516,0.0008503537,0.004035517],"category_scores_gemma":[0.0004655416,0.0002225716,0.0003188165,0.001519935,0.0002698916,0.0009744169,0.0005133589,0.001578329,0.003087595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005525213,"about_ca_system_score_gemma":0.0007115504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006467819,"about_ca_topic_score_gemma":0.0009334014,"domain_scores_codex":[0.9998763,0.00001902108,0.00001548829,0.00002027644,0.00005453809,0.00001434982],"domain_scores_gemma":[0.9998324,0.00005162859,0.0000263518,0.000005542508,0.00006073578,0.00002324944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001151869,0.00008572256,0.0000762574,0.01405912,0.00008954146,0.0001929812,0.0000413993,0.0004397833,0.005392325,0.003889422,0.1517895,0.8238287],"study_design_scores_gemma":[0.0000129589,0.0000536555,0.0002032469,0.0009572834,0.0000421687,0.0004183958,0.00001311676,0.00006328442,0.0007247432,0.0004864775,0.997015,0.000009713667],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001880519,0.9948803,0.0003476615,0.0004629977,0.001785697,0.00001379215,0.00004824388,0.00002322922,0.002249995],"genre_scores_gemma":[0.0008093594,0.995086,0.0003424758,0.0003802885,0.0005746189,0.00001801568,0.0001031155,0.000004284194,0.002681761],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004035517,"threshold_uncertainty_score":0.01350009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09197911540986249,"score_gpt":0.3910999250657445,"score_spread":0.299120809655882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}