{"id":"W2922428728","doi":"10.1371/journal.pone.0213269","title":"Adolescent idiopathic scoliosis associated POC5 mutation impairs cell cycle, cilia length and centrosome protein interactions","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal; Polytechnique Montréal","funders":"Canadian Institutes of Health Research; Government of Canada; Réseau de Recherche en Santé Buccodentaire et Osseuse; Fonds de Recherche du Québec - Santé; Scoliosis Research Society","keywords":"Centrosome; Cilium; Biology; Cell biology; Mutation; Pathogenesis; Motile cilium; Immunoprecipitation; Cytoskeleton; Cell cycle; Microtubule; Genetics; Cell; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005164921,0.0003015024,0.0001549768,0.0002517505,0.0001400442,0.0001675284,0.0001483731,0.0002743751,0.0009838246],"category_scores_gemma":[0.0001288285,0.00008365918,0.000220844,0.0001241363,0.0001729428,0.000115923,0.0001432691,0.0001973131,0.0001759682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001949348,"about_ca_system_score_gemma":0.000169771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001428312,"about_ca_topic_score_gemma":0.001729687,"domain_scores_codex":[0.9999113,0.000008722872,0.00001118203,0.00001850375,0.00003385287,0.00001643438],"domain_scores_gemma":[0.9999126,0.00001364191,0.00003471598,0.000006542029,0.000006918965,0.00002559366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009162685,0.000015599,0.001885903,0.00003680003,0.00001252591,0.0005592966,0.00001481532,0.00007345712,0.9960611,0.00008834463,0.00003825295,0.001122196],"study_design_scores_gemma":[0.00002187063,0.0002692453,0.1114642,0.00002111131,0.00004532534,0.00410663,0.00008165123,0.002624268,0.8790413,0.0001398147,0.002174269,0.00001023676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979391,0.000478607,0.0008041957,0.00003627216,0.00001016015,0.000006656615,0.0003019973,0.00002158322,0.0004015539],"genre_scores_gemma":[0.998134,0.0002799263,0.0006747946,0.00001929245,0.00000248969,0.000006495708,0.0003475805,0.000007605065,0.0005279737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001428312,"threshold_uncertainty_score":0.003291249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009288702536943734,"score_gpt":0.2004209146023369,"score_spread":0.1911322120653932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}