{"id":"W2922479144","doi":"10.1186/s12885-019-5353-6","title":"Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling","year":2019,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":327,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval; The Society of Gynecologic Oncology of Canada; Centre hospitalier universitaire de Québec","funders":"Institute of Musculoskeletal Health and Arthritis; Canadian Urological Association; Ferring; Canadian Institutes of Health Research; Bladder Cancer Canada; Fonds de Recherche du Québec - Santé","keywords":"Epithelial–mesenchymal transition; Vimentin; Cancer-Associated Fibroblasts; Cancer research; Stromal cell; Bladder cancer; Cancer cell; Paracrine signalling; Exosome; Cancer; Medicine; Biology; Pathology; microRNA; Metastasis; Microvesicles; Internal medicine; Immunohistochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002089436,0.0003738051,0.0008728182,0.0001119685,0.00007105134,0.00001884543,0.0001515722,0.0002140091,0.007707232],"category_scores_gemma":[0.00001701785,0.000338919,0.0003420334,0.0005567592,0.0001005939,0.0002147379,0.00003935839,0.0003565454,0.00005307296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005173779,"about_ca_system_score_gemma":0.001089064,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02336498,"about_ca_topic_score_gemma":0.006566299,"domain_scores_codex":[0.9974381,0.0000819073,0.0006248448,0.0006116388,0.0006309001,0.0006125662],"domain_scores_gemma":[0.9986125,0.00009925525,0.0003867872,0.0003642481,0.0003583424,0.0001788656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001070314,0.0003490324,0.005912905,0.001003048,0.0006711868,0.00001114666,0.002153644,0.01395754,0.962517,0.00003211825,0.004408834,0.007913209],"study_design_scores_gemma":[0.005694079,0.0004210641,0.008893382,0.00188778,0.0009563168,0.000005838855,0.0004104485,0.001208323,0.9566478,0.00005939926,0.02321575,0.000599856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98829,0.005823701,0.000422181,0.0007115163,0.001410473,0.0009897531,0.001117206,0.00007562104,0.001159538],"genre_scores_gemma":[0.9879285,0.005901005,0.000593007,0.0008427395,0.0007339736,0.0002603338,0.00005373171,0.00008906205,0.003597717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01880692,"threshold_uncertainty_score":0.9999063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03006305221598811,"score_gpt":0.3007506664874811,"score_spread":0.270687614271493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}