{"id":"W2922479144","doi":"10.1186/s12885-019-5353-6","title":"Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling","year":2019,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":327,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval; The Society of Gynecologic Oncology of Canada; Centre hospitalier universitaire de Québec","funders":"Institute of Musculoskeletal Health and Arthritis; Canadian Urological Association; Ferring; Canadian Institutes of Health Research; Bladder Cancer Canada; Fonds de Recherche du Québec - Santé","keywords":"Epithelial–mesenchymal transition; Vimentin; Cancer-Associated Fibroblasts; Cancer research; Stromal cell; Bladder cancer; Cancer cell; Paracrine signalling; Exosome; Cancer; Medicine; Biology; Pathology; microRNA; Metastasis; Microvesicles; Internal medicine; Immunohistochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893829,0.000271558,0.0002946103,0.0002782473,0.0001815543,0.0003489655,0.00009143224,0.0002066954,0.002423095],"category_scores_gemma":[0.0001896823,0.0001411037,0.000468791,0.0001984321,0.000135272,0.0001874048,0.0002538169,0.0008478421,0.0004467436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001607617,"about_ca_system_score_gemma":0.0002769774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000619932,"about_ca_topic_score_gemma":0.001053492,"domain_scores_codex":[0.9997142,0.00005601185,0.0000337741,0.00004324101,0.00007479711,0.00007797156],"domain_scores_gemma":[0.9998719,0.00002687199,0.00002897702,0.00001798287,0.00002284628,0.00003138211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000325955,0.00015404,0.001245846,0.0002280312,0.00001872253,0.0001439631,0.00008917618,0.0001009852,0.9931867,0.00009499909,0.0004020839,0.004009514],"study_design_scores_gemma":[0.00009115087,0.0008804408,0.02807267,0.0000586862,0.00007091955,0.0006327477,0.000255062,0.001901707,0.9548187,0.000149724,0.01305268,0.00001549502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857049,0.005123547,0.003144117,0.0003738634,0.000151541,0.00008510955,0.001878045,0.0001747208,0.003364086],"genre_scores_gemma":[0.9915575,0.001669799,0.002442318,0.000211911,0.00002922851,0.00009583466,0.001540771,0.00001946966,0.002433241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002423095,"threshold_uncertainty_score":0.008106112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03006305221598811,"score_gpt":0.3007506664874811,"score_spread":0.270687614271493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}