{"id":"W2922530774","doi":"10.1200/jco.2019.37.7_suppl.62","title":"Activity of NEO2734, a novel dual inhibitor of both BET and CBP-P300, in SPOP-mutated prostate cancer.","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Bromodomain; Prostate cancer; Cancer research; BET inhibitor; Cancer; Mutant; Medicine; Downregulation and upregulation; Molecular biology; Epigenetics; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001394572,0.000379539,0.0004079082,0.0003147283,0.0001392728,0.0002090672,0.0003925221,0.0003115064,0.001343123],"category_scores_gemma":[0.00007502681,0.000205186,0.0004334412,0.0002785353,0.0001844489,0.0001700418,0.0001630819,0.0009895307,0.0003599112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003866842,"about_ca_system_score_gemma":0.0005140398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001997417,"about_ca_topic_score_gemma":0.003981151,"domain_scores_codex":[0.9999084,0.00001195733,0.000005807135,0.00001694575,0.00003075463,0.00002603724],"domain_scores_gemma":[0.9999475,0.000006493698,0.00001020311,0.000004755542,0.0000061999,0.00002478265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001422754,0.000827916,0.0008379933,0.0001877109,0.00005336984,0.0001235912,0.00003212298,0.0004246135,0.9849668,0.0001179903,0.0008830413,0.01012199],"study_design_scores_gemma":[0.0006931739,0.009608026,0.01323777,0.00001390161,0.0001613085,0.0009541519,0.00007348885,0.003095182,0.9638644,0.00006955595,0.00820956,0.00001941655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915804,0.003870283,0.0006486819,0.0002162271,0.00006239259,0.00009250375,0.0009949104,0.0001476085,0.002386823],"genre_scores_gemma":[0.9930758,0.002074256,0.0008858516,0.0000836118,0.000009217858,0.00006077252,0.001613516,0.00001780496,0.002179227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001997417,"threshold_uncertainty_score":0.004493237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0355274068530394,"score_gpt":0.4001736102346286,"score_spread":0.3646462033815892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}