{"id":"W2922559180","doi":"10.1212/wnl.0000000000007262","title":"Effect of dimethyl fumarate on lymphocytes in RRMS","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Biogen","keywords":"Discontinuation; Immunophenotyping; CD8; Lymphocyte; Dimethyl fumarate; Lymphocytopenia; Incidence (geometry); Immune system; Immunology; Flow cytometry; Internal medicine; Medicine; T cell; Adverse effect; Multiple sclerosis; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001050406,0.0003599853,0.00072078,0.0002783901,0.0001552901,0.0003125374,0.0002332737,0.0003323507,0.001243148],"category_scores_gemma":[0.00119165,0.00008749098,0.0004291387,0.0001906453,0.0001871655,0.0002319006,0.0001981118,0.0003906277,0.0002040361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002728088,"about_ca_system_score_gemma":0.0001594155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004368184,"about_ca_topic_score_gemma":0.0008148479,"domain_scores_codex":[0.9994295,0.000290189,0.00004606158,0.00006933932,0.0001040976,0.00006068717],"domain_scores_gemma":[0.9994746,0.000175902,0.0002014614,0.00002528267,0.00006093069,0.00006183759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1147204,0.001743821,0.2089633,0.002663189,0.001318806,0.0009605722,0.0005525295,0.001224165,0.2975825,0.0001910095,0.0009466183,0.3691332],"study_design_scores_gemma":[0.003824095,0.1703827,0.6707843,0.0006263028,0.00211331,0.004992109,0.0004577665,0.002334178,0.1298911,0.0004090462,0.01413099,0.00005402809],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795975,0.01863682,0.0003057336,0.000124733,0.00003343259,0.00006061334,0.0001666682,0.00002994703,0.00104453],"genre_scores_gemma":[0.9981457,0.001123668,0.000232561,0.00007646517,0.0000274111,0.00002921655,0.00008003736,0.00000336536,0.000281677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243148,"threshold_uncertainty_score":0.005555153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01690861016205026,"score_gpt":0.320390545276035,"score_spread":0.3034819351139847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}