{"id":"W2922569119","doi":"10.1371/journal.ppat.1007662","title":"Full restoration of specific infectivity and strain properties from pure mammalian prion protein","year":2019,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Infectivity; Prion protein; Biology; Cofactor; Virology; Strain (injury); Cell biology; Chemistry; Biochemistry; Virus; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003779485,0.0003997464,0.0002724199,0.0002314965,0.0001159601,0.0003573484,0.0002917573,0.0002298525,0.0006988455],"category_scores_gemma":[0.0003513215,0.0001736802,0.0003213593,0.0001213657,0.0002550424,0.0002444206,0.0003556588,0.0008257414,0.0004053015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001290731,"about_ca_system_score_gemma":0.0001968632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002546893,"about_ca_topic_score_gemma":0.0004269207,"domain_scores_codex":[0.999813,0.00003711928,0.00002242137,0.00003851263,0.00005985245,0.00002915171],"domain_scores_gemma":[0.9996287,0.00007266414,0.00007046276,0.0001313776,0.00003391713,0.0000629206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000216111,0.00001372433,0.0001248431,0.00001913551,0.000006011096,0.00003803364,0.0000123487,0.00003267922,0.998691,0.00009669347,0.00001724569,0.0009267244],"study_design_scores_gemma":[0.000004925562,0.0002880529,0.004493715,0.000007209056,0.00002158135,0.0005942678,0.00002203063,0.0008394281,0.9912185,0.000134383,0.002368916,0.000006943177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824449,0.001801303,0.01278865,0.00007028331,0.00005063591,0.00004243073,0.0004155686,0.0002457962,0.002140473],"genre_scores_gemma":[0.9908814,0.0006268908,0.005192676,0.00004941277,0.0000101847,0.00001358921,0.0009591324,0.00008564133,0.002181019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006988455,"threshold_uncertainty_score":0.002337813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521396381950916,"score_gpt":0.204998758736305,"score_spread":0.1897847949167959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}