{"id":"W2922569119","doi":"10.1371/journal.ppat.1007662","title":"Full restoration of specific infectivity and strain properties from pure mammalian prion protein","year":2019,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Infectivity; Prion protein; Biology; Cofactor; Virology; Strain (injury); Cell biology; Chemistry; Biochemistry; Virus; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009628131,0.0001051951,0.0001178411,0.00002406113,0.00003553339,0.00002037594,0.00006688845,0.0001029413,0.00005045654],"category_scores_gemma":[0.00004383662,0.00009488174,0.00004559689,0.00004017141,0.00003441191,0.000007680417,0.00006773366,0.0000545269,0.000009292717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000887511,"about_ca_system_score_gemma":0.00003674991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001416214,"about_ca_topic_score_gemma":0.00001937252,"domain_scores_codex":[0.9992952,0.00007880817,0.000136549,0.0002624571,0.0001097617,0.0001172583],"domain_scores_gemma":[0.9995503,0.000003851013,0.00008565139,0.0002550201,0.00005291288,0.00005231141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001638477,0.00005778506,0.01088102,0.00006205869,0.00001983664,0.000001176912,0.00006078814,0.000007707652,0.9811637,0.00004003529,0.0000144087,0.007527583],"study_design_scores_gemma":[0.0003749561,0.0004603118,0.0294591,0.00008325599,0.00001579135,0.000001415789,0.00005965518,0.00007745799,0.9674842,0.0001922531,0.001616454,0.000175125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963375,0.002609403,0.0001514051,0.00005464797,0.00003192986,0.0005688739,0.0001727596,0.000009891581,0.00006357388],"genre_scores_gemma":[0.9989054,0.0002381607,0.0005297263,0.00001573611,0.0001009246,0.00002840991,0.00010678,0.00001427797,0.00006063855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01857808,"threshold_uncertainty_score":0.3869165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521396381950916,"score_gpt":0.204998758736305,"score_spread":0.1897847949167959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}