{"id":"W2922637566","doi":"10.1016/j.ebiom.2019.03.051","title":"A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions","year":2019,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; John Abbott College; Douglas Mental Health University Institute; University of British Columbia; McGill University","funders":"Faculty of Medicine, Prince of Songkla University; Jacobs Foundation; Fondation Brain Canada; McGill University; JPB Foundation; Health Research","keywords":"Endophenotype; Brain function; Biology; Function (biology); Computational biology; Bioinformatics; Insulin receptor; Medicine; Insulin; Neuroscience; Internal medicine; Genetics; Insulin resistance; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009638398,0.0007118637,0.0004850492,0.002006636,0.0002905268,0.0006933481,0.0003313958,0.0004322937,0.004171165],"category_scores_gemma":[0.002900116,0.0001159123,0.001051411,0.00171584,0.0003698083,0.000215604,0.0007675721,0.0004316951,0.0003690168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002045814,"about_ca_system_score_gemma":0.0003131993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001895682,"about_ca_topic_score_gemma":0.003472589,"domain_scores_codex":[0.9992706,0.0002684727,0.00007353024,0.0002053802,0.0001185095,0.00006355167],"domain_scores_gemma":[0.998423,0.0006677556,0.0004735133,0.0002052393,0.0001245704,0.0001059765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005711896,0.00006912203,0.9669495,0.00007089596,0.001419049,0.0002108218,0.00009186289,0.002487556,0.007528074,0.0005353067,0.0005283306,0.01953828],"study_design_scores_gemma":[0.00003029065,0.0002151595,0.991088,0.00001494997,0.0003207886,0.0004650339,0.00006022688,0.005516422,0.0006099382,0.001008778,0.0006547721,0.00001556436],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872267,0.000159458,0.008611129,0.00009543001,0.000009318013,0.0000399817,0.002987659,0.00007594418,0.0007943261],"genre_scores_gemma":[0.9883499,0.00008175575,0.007880638,0.000026407,0.00001455624,0.00005878372,0.003216044,0.00001644628,0.0003552978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004171165,"threshold_uncertainty_score":0.01395392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05285442250293348,"score_gpt":0.3300432763834982,"score_spread":0.2771888538805647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}