{"id":"W2922667293","doi":"10.1007/978-981-13-3681-2_2","title":"The Immune System and Its Dysregulation with Aging","year":2019,"lang":"en","type":"review","venue":"Sub-cellular biochemistry/Subcellular biochemistry","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":308,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences North","funders":"","keywords":"Immune system; Thymic involution; Immunosenescence; Neuroinflammation; Immunology; Acquired immune system; Inflammation; Disease; Immune dysregulation; Biology; Context (archaeology); Neuroscience; T cell; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0006118788,0.001400006,0.001521906,0.0001369,0.001035269,0.0007024216,0.001263838,0.0008200082,0.00002511326],"category_scores_gemma":[0.0003202569,0.001048894,0.0005722673,0.0007773789,0.0003052873,0.0001422472,0.0004498466,0.001072372,0.0002582701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003032096,"about_ca_system_score_gemma":0.0006008847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001441893,"about_ca_topic_score_gemma":2.653499e-7,"domain_scores_codex":[0.9938582,0.000393577,0.001438632,0.0022545,0.001106672,0.0009484818],"domain_scores_gemma":[0.9955393,0.0004492479,0.00144423,0.002015011,0.0001788118,0.0003733895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002213314,0.00003825576,1.226971e-7,0.01673134,0.00005222985,0.0001407971,0.00001035373,0.000005133769,0.9625805,0.0007315526,0.00004918759,0.01963841],"study_design_scores_gemma":[0.0005011401,0.00004051283,1.827489e-8,0.003401969,0.0004040476,0.000764196,0.0000362283,0.000572013,0.8885183,0.000005284599,0.1047275,0.001028753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008784045,0.9873794,0.0003105011,0.00008586795,0.000538879,0.001548189,0.0001256765,0.0004439317,0.0007835042],"genre_scores_gemma":[0.05727671,0.9315788,0.0000495538,0.00003896542,0.0006138624,0.0002488913,0.0005827522,0.0003526536,0.009257792],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1046783,"threshold_uncertainty_score":0.999875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02677957848693889,"score_gpt":0.2473478578483187,"score_spread":0.2205682793613798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}