{"id":"W2922682617","doi":"10.1242/dev.173146","title":"Defined conditions for propagation and manipulation of mouse embryonic stem cells","year":2019,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; Seventh Framework Programme; Medical Research Council Canada; Wellcome Trust","keywords":"Biology; Embryonic stem cell; Stem cell; Epigenetics; Phenotype; Cell biology; Embryo; Developmental biology; Cellular differentiation; Epigenesis; Cell; Immunology; Genetics; Computational biology; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002013632,0.001504176,0.0009678528,0.002003835,0.001430346,0.001091261,0.001615211,0.0010018,0.005163374],"category_scores_gemma":[0.001629933,0.0008826492,0.000692129,0.001318078,0.000938078,0.000634849,0.001340609,0.002220416,0.00731957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005411851,"about_ca_system_score_gemma":0.001702775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001051686,"about_ca_topic_score_gemma":0.002814982,"domain_scores_codex":[0.9977945,0.0003820595,0.0004428097,0.0003805057,0.0007935617,0.0002064798],"domain_scores_gemma":[0.99883,0.0002254344,0.0002689711,0.0003085207,0.0002557431,0.0001112457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000103015,0.00008210998,0.0002709163,0.0003471161,0.000009293482,0.0002218475,0.0002411816,0.0003653429,0.9850709,0.002224891,0.001087112,0.009976329],"study_design_scores_gemma":[0.00004126104,0.0002709571,0.002698449,0.0002098821,0.00005396039,0.0007030001,0.0001003667,0.0008394005,0.8790202,0.000846174,0.1151375,0.00007874887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1500774,0.01049495,0.7538143,0.0007418538,0.001078544,0.01516431,0.02882186,0.004461367,0.03534546],"genre_scores_gemma":[0.1318,0.01476895,0.7503717,0.000674598,0.0002623716,0.03089278,0.0449259,0.002157347,0.02414634],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.005163374,"threshold_uncertainty_score":0.01727319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01845231434481906,"score_gpt":0.2535642985795638,"score_spread":0.2351119842347447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}