{"id":"W2922682617","doi":"10.1242/dev.173146","title":"Defined conditions for propagation and manipulation of mouse embryonic stem cells","year":2019,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; Seventh Framework Programme; Medical Research Council Canada; Wellcome Trust","keywords":"Biology; Embryonic stem cell; Stem cell; Epigenetics; Phenotype; Cell biology; Embryo; Developmental biology; Cellular differentiation; Epigenesis; Cell; Immunology; Genetics; Computational biology; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148269,0.00005800316,0.00006773951,0.00003592817,0.00003360659,0.000007272815,0.00004743758,0.00005061645,0.000008236359],"category_scores_gemma":[0.000003801773,0.00005621292,0.00001744872,0.00003021499,0.0000138926,0.000002749126,0.00004211386,0.00001861273,0.00001574824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001851917,"about_ca_system_score_gemma":0.00008707232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001353395,"about_ca_topic_score_gemma":0.000005633862,"domain_scores_codex":[0.9995074,0.00001462644,0.0001261318,0.0001570496,0.00008946403,0.0001053319],"domain_scores_gemma":[0.9997458,0.000008945207,0.00005135425,0.0001020518,0.00006405958,0.00002772177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002635747,0.00002177284,0.002109591,0.0001040923,0.00002138423,6.774084e-8,0.00003502573,0.0001043724,0.9966934,0.0001341677,0.0002193256,0.0005304771],"study_design_scores_gemma":[0.0004551868,0.00008036123,0.00717595,0.00001043316,0.000003303815,0.00000109738,0.00003103405,0.0003719877,0.9862864,0.00001245641,0.005498325,0.00007347012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967758,0.00004669342,0.002384283,0.00004410992,0.00004056105,0.0005569226,0.00001330639,0.000004203239,0.0001341022],"genre_scores_gemma":[0.9923761,0.00001951167,0.001435782,0.00001573815,0.000008932041,0.00005449203,0.0002401627,0.000009117727,0.005840158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01040697,"threshold_uncertainty_score":0.2292297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01845231434481906,"score_gpt":0.2535642985795638,"score_spread":0.2351119842347447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}