{"id":"W2922795992","doi":"10.1371/journal.ppat.1007511","title":"Bacterial fitness in chronic wounds appears to be mediated by the capacity for high-density growth, not virulence or biofilm functions","year":2019,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Burroughs Wellcome Fund; Cystic Fibrosis Foundation; Canada Research Chairs","keywords":"Biofilm; Virulence; Pseudomonas aeruginosa; Biology; Microbiology; Pathogenesis; Chronic wound; Bacteria; Chronic infection; Pathogen; Gene; Human pathogen; Anaerobic exercise; Ex vivo; In vivo; Wound healing; Immunology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002869963,0.0002987381,0.0003746352,0.0002490924,0.0003543784,0.000753009,0.0001439453,0.0003317514,0.001593078],"category_scores_gemma":[0.0002734024,0.0001310016,0.0002240288,0.0001791009,0.0004677106,0.0005000689,0.0006082275,0.000527536,0.0003388111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872083,"about_ca_system_score_gemma":0.0002444187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000581039,"about_ca_topic_score_gemma":0.0008888346,"domain_scores_codex":[0.999795,0.00002621222,0.00001670681,0.00003863282,0.00006976445,0.00005380173],"domain_scores_gemma":[0.9995986,0.00005703541,0.0001316969,0.00003163552,0.00006649876,0.000114624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006250308,0.00002598744,0.006523436,0.00006790031,0.000006482334,0.00006088506,0.00005516278,0.0000219171,0.9899811,0.0001358271,0.00003519224,0.003023528],"study_design_scores_gemma":[0.00001225655,0.001394216,0.4077192,0.00008122772,0.00003675259,0.002980892,0.001178659,0.0009963658,0.5815929,0.0009911221,0.002982321,0.00003401118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932423,0.002024089,0.003375985,0.000270582,0.00001315392,0.00001636264,0.0001692113,0.00002039084,0.0008679201],"genre_scores_gemma":[0.9966343,0.001044946,0.001333897,0.00004112889,0.000007494513,0.00001171047,0.0001552549,0.000008968056,0.0007624494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001593078,"threshold_uncertainty_score":0.00532937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972754008259524,"score_gpt":0.2224634099910561,"score_spread":0.2027358699084608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}