{"id":"W2922795992","doi":"10.1371/journal.ppat.1007511","title":"Bacterial fitness in chronic wounds appears to be mediated by the capacity for high-density growth, not virulence or biofilm functions","year":2019,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Burroughs Wellcome Fund; Cystic Fibrosis Foundation; Canada Research Chairs","keywords":"Biofilm; Virulence; Pseudomonas aeruginosa; Biology; Microbiology; Pathogenesis; Chronic wound; Bacteria; Chronic infection; Pathogen; Gene; Human pathogen; Anaerobic exercise; Ex vivo; In vivo; Wound healing; Immunology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002286078,0.0002290237,0.0002522561,0.00004538899,0.0001472149,0.00005506391,0.0002207242,0.0002597751,0.0000876424],"category_scores_gemma":[0.0002050843,0.0001708196,0.00008875135,0.0001900421,0.00008332953,0.00000983199,0.0001317284,0.0001272895,0.00005595832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007737076,"about_ca_system_score_gemma":0.0001410254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002227613,"about_ca_topic_score_gemma":0.001010916,"domain_scores_codex":[0.998518,0.00009156469,0.0002675134,0.0005274065,0.0001431866,0.0004523327],"domain_scores_gemma":[0.9991853,0.00005766591,0.00008834589,0.000438575,0.0001213592,0.0001088113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005022411,0.00006401099,0.0003656884,0.00002936964,0.00003939615,0.000001575954,0.00005474699,0.000004245691,0.9973083,0.00002425426,0.001206913,0.0003993068],"study_design_scores_gemma":[0.001011562,0.0006262714,0.004466165,0.00002778798,0.00003694435,0.00000852303,0.00005254577,0.00005384987,0.9783367,0.000005054756,0.01503961,0.0003349853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959089,0.00002156651,0.0001107864,0.001006697,0.0007521461,0.0007378557,0.001404422,0.0000231893,0.00003443561],"genre_scores_gemma":[0.9969468,0.00003358767,0.0004384171,0.0008532154,0.0004661384,0.00005806526,0.0007675245,0.00003578901,0.0004005349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01897155,"threshold_uncertainty_score":0.6965822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972754008259524,"score_gpt":0.2224634099910561,"score_spread":0.2027358699084608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}