{"id":"W2922818580","doi":"10.1038/s41598-019-41102-7","title":"Characterization of an HPV33 natural variant with enhanced transcriptional activity suggests a role for C/EBPβ in the regulation of the viral early promoter","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; Centre Hospitalier de l’Université de Montréal; McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Promoter; Biology; Promoter activity; Genetics; Computational biology; Gene; Molecular biology; Cell biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469206,0.0003021063,0.0001998364,0.0002084579,0.0001647258,0.0002168397,0.0001661432,0.0002148806,0.001684947],"category_scores_gemma":[0.0002596675,0.00009504105,0.0004309293,0.0001815649,0.0002685399,0.00009133909,0.0001782122,0.0005180565,0.0004018833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002525204,"about_ca_system_score_gemma":0.0001901856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000590532,"about_ca_topic_score_gemma":0.0007812071,"domain_scores_codex":[0.9998982,0.00001851694,0.00001310415,0.00002207964,0.0000233361,0.0000247558],"domain_scores_gemma":[0.9997192,0.00007688649,0.00005807511,0.00005757324,0.00003555624,0.00005280427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004493868,0.00002234176,0.0005825394,0.00001327241,0.000003757018,0.00008448122,0.00001198816,0.00002469748,0.9986041,0.00006789155,0.000009199267,0.0005307376],"study_design_scores_gemma":[0.00001706938,0.0008354912,0.02589214,0.00001370614,0.00004588659,0.004617839,0.00008632255,0.001065883,0.9640886,0.0001132234,0.003209642,0.00001420663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961462,0.0002778053,0.002787154,0.00003219205,0.00001458412,0.00003406952,0.0003243719,0.00002279315,0.0003608406],"genre_scores_gemma":[0.9949529,0.000201548,0.002708694,0.00003013986,0.000007819724,0.00002668999,0.001424107,0.00003086611,0.0006172546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001684947,"threshold_uncertainty_score":0.005636692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124315441305584,"score_gpt":0.2714722345103466,"score_spread":0.2602290800972908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}