{"id":"W2923004347","doi":"10.1186/s13058-019-1126-z","title":"Breast cancer risk prediction in women aged 35–50 years: impact of including sex hormone concentrations in the Gail model","year":2019,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centers for Disease Control and Prevention; National Institute of Environmental Health Sciences; National Institute for Health and Care Research; York University; Avon Foundation for Women; National Cancer Institute; National Institutes of Health; Cancer Research UK; U.S. Department of Defense","keywords":"Surgical oncology; Breast cancer; Medicine; Oncology; Cancer; Internal medicine; Sex hormone-binding globulin; Hormone; Gynecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0272063,0.002113324,0.003013185,0.002572967,0.0005554942,0.002533777,0.003090142,0.001451075,0.002261484],"category_scores_gemma":[0.03867865,0.0008249887,0.007996444,0.001550219,0.0006013334,0.001301268,0.001496252,0.002737921,0.0006698667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00107045,"about_ca_system_score_gemma":0.001603954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01470305,"about_ca_topic_score_gemma":0.008856722,"domain_scores_codex":[0.9891516,0.008480711,0.0003973995,0.00125988,0.000440316,0.0002700845],"domain_scores_gemma":[0.9474099,0.0466968,0.002029317,0.001733961,0.001548404,0.0005816005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.009829029,0.0003471227,0.3042087,0.001573477,0.03192304,0.0006970497,0.0002297649,0.5756249,0.000718324,0.002560205,0.00484234,0.06744591],"study_design_scores_gemma":[0.0006159479,0.0009897655,0.02176814,0.0003934498,0.01226216,0.0004574342,0.00008575081,0.9527093,0.0003233931,0.007899092,0.002374094,0.0001214738],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.660817,0.05738161,0.25607,0.009367744,0.00108269,0.0005390432,0.006584642,0.002195093,0.005962285],"genre_scores_gemma":[0.9707677,0.002335773,0.02294739,0.0008359067,0.0002154311,0.0001912212,0.001585392,0.0001161972,0.001004862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0272063,"threshold_uncertainty_score":0.1438824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03541111122403194,"score_gpt":0.3757625253866045,"score_spread":0.3403514141625725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}