{"id":"W2923023620","doi":"10.1101/585604","title":"Human Hepatocyte Nuclear Factor 4-α encodes isoforms with distinct transcriptional functions","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Gene isoform; Alternative splicing; Biology; Transcription factor; Hepatocyte nuclear factor 4; Exon; Computational biology; Hepatocyte nuclear factors; Cell biology; Transcriptome; Proteome; RNA splicing; Nuclear receptor; Promoter; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000227365,0.0002903058,0.0002023553,0.0003782263,0.000156148,0.0004722655,0.0001302079,0.0001600338,0.00131692],"category_scores_gemma":[0.0002216204,0.0001765477,0.0003515276,0.0004874627,0.0001610464,0.0001727573,0.0001662408,0.0003503961,0.001040021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000330822,"about_ca_system_score_gemma":0.0002630843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009633665,"about_ca_topic_score_gemma":0.0009446199,"domain_scores_codex":[0.9998021,0.00002109237,0.00001727299,0.00006618554,0.00005970203,0.0000337497],"domain_scores_gemma":[0.9998153,0.00003481857,0.00005642021,0.00003338428,0.00003508205,0.0000251222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004489154,0.00001364748,0.005703712,0.00006498657,0.00002936091,0.0002058793,0.00004977844,0.0001548941,0.983678,0.0002989382,0.0002262343,0.009125735],"study_design_scores_gemma":[0.00008478027,0.0003394066,0.1046985,0.00004540099,0.0001267382,0.003661753,0.0002215099,0.00330241,0.8446636,0.001409644,0.04141436,0.00003197693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719837,0.004022667,0.01400566,0.000224878,0.00008335934,0.00003245562,0.007071617,0.0002416695,0.002334082],"genre_scores_gemma":[0.950168,0.002255588,0.01416876,0.0001822294,0.000054346,0.00003441306,0.02579656,0.00008730037,0.007252881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00131692,"threshold_uncertainty_score":0.004405499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01913586778721364,"score_gpt":0.2237297842423542,"score_spread":0.2045939164551406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}