{"id":"W2923047128","doi":"10.3389/fnagi.2019.00062","title":"Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/β-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer’s Disease","year":2019,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Chongqing Medical University; National Natural Science Foundation of China","keywords":"Neurogenesis; Dentate gyrus; Wnt signaling pathway; Nestin; Hippocampus; Genetically modified mouse; Hippocampal formation; Amyloid precursor protein; Neuroscience; Biology; Neural stem cell; Transgene; Cell biology; Alzheimer's disease; Internal medicine; Medicine; Signal transduction; Stem cell; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001218896,0.0005205148,0.0006162846,0.0004511564,0.0001832787,0.0003033954,0.000248953,0.0004283046,0.0006082809],"category_scores_gemma":[0.00007242052,0.0002443479,0.0005182592,0.0002296844,0.0002868614,0.0003253434,0.0001857271,0.001065516,0.000178115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003070637,"about_ca_system_score_gemma":0.0002995158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009702668,"about_ca_topic_score_gemma":0.001861242,"domain_scores_codex":[0.9998616,0.00001582542,0.00002412455,0.00003230731,0.00003047957,0.0000356977],"domain_scores_gemma":[0.9999273,0.000004699129,0.00002306116,0.000005850112,0.000006919812,0.00003218965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007072873,0.0001823564,0.0002383653,0.0001002407,0.00001536356,0.0001016514,0.00003203524,0.00006925748,0.996935,0.00005965814,0.00007012347,0.001488734],"study_design_scores_gemma":[0.000260776,0.00344179,0.009272088,0.00003242549,0.0001151602,0.000381375,0.00009210826,0.001320752,0.9816571,0.0001707558,0.003237214,0.00001837999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951063,0.002437619,0.0008706471,0.0001420243,0.00007137005,0.00003968161,0.0004851067,0.0001015097,0.0007456438],"genre_scores_gemma":[0.9898539,0.003593024,0.002516983,0.0001353814,0.00002844611,0.0001433296,0.000747745,0.00002774304,0.002953589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009702668,"threshold_uncertainty_score":0.002227962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04663630235220138,"score_gpt":0.2522901685817011,"score_spread":0.2056538662294997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}