{"id":"W2923061882","doi":"10.1124/mol.118.114389","title":"Characterization of 6-Mercaptopurine Transport by the SLC43A3-Encoded Nucleobase Transporter","year":2019,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; University of Alberta; Cancer Research Society","keywords":"HEK 293 cells; Nucleobase; Chemistry; Transporter; Transfection; Extracellular; Membrane transport protein; Efflux; Biochemistry; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138835,0.0001717381,0.000195313,0.00003435561,0.00003649084,0.000003773925,0.0002582564,0.0001278999,0.0006567729],"category_scores_gemma":[0.000002343829,0.000140332,0.0001323487,0.0001094107,0.00008131471,0.000005371302,0.00002522025,0.0001152983,0.00001800173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005972573,"about_ca_system_score_gemma":0.00004329841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001552724,"about_ca_topic_score_gemma":6.231833e-7,"domain_scores_codex":[0.9989505,0.0000861145,0.0002895008,0.000306078,0.000132644,0.0002351322],"domain_scores_gemma":[0.999497,0.000007366214,0.0001193354,0.0002519602,0.00006654906,0.00005781854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001586218,0.00009817855,0.001677585,0.00002635643,0.0001098677,0.0000123141,0.00005739559,0.0001213531,0.9942012,0.00004111145,0.003357476,0.0001385398],"study_design_scores_gemma":[0.001057488,0.0001939011,0.001008164,0.000004881023,0.00008371252,0.00001792466,0.0000138484,0.00008519835,0.9517432,0.000007429123,0.0456249,0.0001593196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927993,0.0007124997,0.004648556,0.0005259516,0.0002547862,0.0003667841,0.0000610576,0.00001319218,0.0006178291],"genre_scores_gemma":[0.9962034,0.000112186,0.00005066841,0.001849523,0.0001032012,0.00002874487,0.0006283861,0.00003276554,0.0009911899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04245796,"threshold_uncertainty_score":0.7191203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003676902508598354,"score_gpt":0.2244829165910244,"score_spread":0.220806014082426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}